Month: June 2021

Sport

Vegas Golden Knights even wish to compete with the Colorado Avalanche

Post author By Mans Life Daily
Post date June 6, 2021

The New York Islanders finished their streak 2-2 on Saturday thanks to a boost from viewers at the Nassau Coliseum. Can the Vegas Golden Knights in the West do the same against the Colorado Avalanche on Sunday night at the T-Mobile Arena?

Meanwhile, the Montreal Canadiens head to their home ice as the Winnipeg Jets face a fight or their post-season hopes may soon end.

Check out the ESPN NHL Playoffs Daily for the latest news every day of the postseason until the Stanley Cup awards ceremony in July.

More: Playoff Schedule | Playoff headquarters

Games on Sunday

Game 3: Winnipeg Jets at Montreal Canadiens | 6 p.m. (Canadians lead 2-0)

The series moves back to Montreal, where the Habs can bring the Jets to the brink of elimination with another win. The crazy jets suddenly look like outsiders, but exude confidence. Winnipeg will once again be without one of their best strikers, Mark Scheifele (who is serving the second game with a four-game suspension) and one of their best defenders, Dylan DeMelo (at least a week due to injury), but could welcome their veteran center Paul Stastny back . That could help the Jets generate some offensive as they only scored three goals in two games.

Montreal and its closed playoff goalkeeper Carey Price didn’t have much rest. Since games 3 and 4 are played on consecutive days, the Habs will have played 11 games in just 19 days.

2 relatives

Game 4: Colorado Avalanche at Vegas Golden Knights | 8:30 p.m. (Avs lead 2-1)

The Golden Knights fell 2-0 down that series, but they weren’t afraid: they just hadn’t been to the keep yet. In front of more than 17,000 fans on the home ice in the T-Mobile Arena, Vegas scored two goals in less than three minutes in the third period to win Game 3 and make this series interesting. The expanded stats show the dominance of the Golden Knights – they controlled 75% of the proportion of high-risk shot attempts – and the Avs weren’t happy with their performance as it dates back to Game 2. “The simple answer is: for five you were now much more competitive than us,” said coach Jared Bednar. “Analyzing the game further is a waste of time.”

One thing that speaks for Colorado is still Mikko Rantanen, who has a 17-game point streak in the playoffs. The top striker has also scored points in 22 of his last 23 playoff games.

Because of last night

Tampa Bay Lightning 6, Carolina Hurricanes 4 (lightning lead 3-1)

Tampa Bay led 1-0 after the first third. And then it went wrong. In the second period, each team scored four goals as the Lightning quickly turned a 4-2 deficit into a 5-4 lead.

Four unanswered goals?

Well why not 🤷‍♂️ pic.twitter.com/MFz23L7XJk

– Tampa Bay Lightning (@TBLightning) June 5, 2021

The death of the Canes gave the Lightning too many power games. “Well, we took too many penalties,” said coach Rod Brind’Amour. “You can’t take the penalties whether you get or not [your own] calling or not. You can’t take the risk. “The real reason the Canes can’t take so many: Tampa Bay’s powerplay works on another level. The Lightning had a 3-6 advantage in this game and scored five powerplay goals in the last game.” two games alone but the Canes should feel comfortable if they score four goals against Andrei Vasilevsky. Complete summary

New York Islanders 4, Boston Bruins 1 (2-2)

Another big night at the Colosseum. It was an awkward start for the Bruins as David Pastrnak had a wide open net and hit the post. “If your best player hits the post on an open net, it will be one of those nights when we are unlikely to take breaks,” said Bruins coach Bruce Cassidy. “We have to earn it.”

Pastrnak with the cage wide open meets iron pic.twitter.com/JfYRWmFYCf

– Rob Taub (@RTaub_) June 5, 2021

David Krejci opened the gate for Boston, but Kyle Palmieri did the same. Mathew Barzal then scored his second goal in as many games. It was a massive game as it broke a 1-1 draw late in the third. Barzal also supported Palmieri’s goal. Complete summary

Three stars of the night

Mathew Barzal, C, New York Islanders

New York’s most capable striker has failed to score in the Islanders’ first eight playoff games. He has now scored a goal in two games in a row, both played in the Isles barn.

OUR. HOUSE. # Isles @NYIslanders pic.twitter.com/WpzGJy1XpM

– x – Islands on MSG + (@IslesMSGN) June 6, 2021

Steven Stamkos, C, Tampa Bay Lightning

In the second period, Stamkos scored two of Tampa Bay’s four goals. The Lightning Captain added an assist (also in the second) for his best performance this postseason.

Nikita Kucherov, RW, Tampa Bay Lightning

The 2018-19 MVP scored two goals and added an assist that earned them an impressive 17 points in 10 payout games. Since Kucherov debuted in 2014, no player has played more three-point playoffs than his 14th.

Unexpected moment of the night

Taylor Hall has been a revelation for Boston since the trading deadline. He’s humming in the second row with David Krejci and Craig Smith, bringing up the kind of offensive numbers everyone in Buffalo was hoping for.

Hall wasn’t shy about staying with the Bruins this season. He’s a smart guy, he knows what he’s doing. So what better way to popularize the Boston fan base than …

Taylor Hall challenges and fights against Scott Mayfield in Game 4 pic.twitter.com/q7gfCfqDFq

– Brady Trettenero (@BradyTrett) June 5, 2021

According to hockeyfights.com, this was Hall’s second fight since 2011. If management doesn’t sign him to a new contract this summer, fans in Boston could revolt.

Science

What Would It Take To See Synthetic Lights at Proxima Centauri B?

Post author By Mans Life Daily
Post date June 6, 2021

Is there an alien civilization next door? It’s…possible(ish). In late 2020, we discovered a signal from the direction of Proxima Centauri (not necessarily from Proxima Centauri), our closest neighbour star. Named BLC- 1 by project Break Through Listen, the signal is still being analyzed to ensure it isn’t simply an echo of our own civilization – typically what they turn out to be. But why not just directly look at planets in Proxima Centauri and see if a civilization is there?

From space, the most obvious sign somebody lives on Earth is the glow from the nightside of our planet. Our cities emit light that’s shed into the Cosmos. Problem is that our current generation of telescopes are not powerful enough to see lights on distant worlds. But several researchers are testing the capabilities of the next generation of telescopes already on the drawing board. The finding? Yes! if advanced enough…or glowy enough…we would be able to see if another civilization has the lights on at Proxima Centauri.

https://www.youtube.com/watch?v=uyHbnmgxxG4

8k compilation of footage taken from the International Space Station orbiting above Earth’s City Lights

Webb Cam

There are several ways you could tell alien technology exists on another planet. For example, we may be able to see the light of a distant world waver with the transit of a massive constellation of satellites (a direction we’re headed in). Atmospheric pollution may be detectable from nuclear conflict (ouch). But while these indications of technology could also be caused by natural phenomenon like orbiting debris or a comet impact, artificial illumination is distinct from the natural light of stars. Elisa Tabor of Stanford University and Abraham Loeb of Harvard University took the James Webb Space Telescope (JWST) for a virtual alien light hunting test drive. James Webb hasn’t actually launched yet so the research tests the paper specs of JWST’s capabilities.

The virtual JWST is trained on Proxima b – the one confirmed planet in the Proxima Centauri system that could host a civilization. Located 4.25 light years from Earth, Proxima b is a rocky world in the habitable zone of the M-class red dwarf star Proxima Centauri – a mere 12% the mass of our Sun. Proxima b is more hefty than us at about 1.6 Earth masses and 1.3 times our radius. It orbits Proxima Centauri in just 11.2 days at a distance of a 7 million km – only 5% of the distance at which Earth orbits the Sun.

Confirmed planets at Proxima Centauri! – Video by Fraser Cain – Universe Today

Tabor and Loeb scaled artificial illumination as a fraction of the solar illumination reflecting from the dayside of the planet. 0% on this scale would assume that the nightside of the planet is completely dark, devoid of artificial illumination. 100% means the nightside of the planet is as equally bright as the dayside. The type of light used by the hypothetical civilization on Proxima b is assumed to be similar to LEDs on Earth which have a distinct artificial spectrum. The results? If the artificial nightside illumination of Proxima b reaches 5% of the natural dayside illumination JWST could detect the artificial light with 85% certainty. If artificial illumination were to reach 9% JWST’s detection confidence rises to 95%.

5% illumination doesn’t sound like much, right? Well, we are talking about the light from a star. As faint as Proxima Centauri is compared to our Sun (about 20,000 times dimmer), that’s still a lot of light. By comparison, Earth’s artificial illumination is only 0.001% of reflected stellar illumination. In other words, if Proxima b hosts a civilization as glowy as us, JWST wouldn’t detect it. Those lights would need to be 500 times brighter. That scenario is plausible. Proxima b orbits so closely to its host star that it may be tidally locked – one side of the planet always faces the star while the other is in perpetual night. A civilization on a tidally locked planet may need to focus on illumination infrastructure and could possibly, as Tabor and Loeb hypothesize, use very bright orbital mirrors to reflect sunlight onto the nightside of the planet which could be seen by our telescopes.

This infographic compares the orbit of the planet around Proxima Centauri (Proxima b) with the same region of the Solar System. Proxima Centauri is smaller and cooler than the Sun and the planet orbits much closer to its star than Mercury. As a result it lies well within the habitable zone, where liquid water can exist on the planet’s surface.

Next, Next Gen: LUVOIR and HabEx

Tabor and Loeb indicate that other future telescopes such as LUVOIR (Large UV Optical Infrared Surveyor) may be even more capable than JWST at spotting the glow of a distant civilization. Just a few days after their publication, Thomas Beatty of the Department of Astronomy at the University of Tucson, crunched just those numbers. Beatty reviewed both LUVOIR as well as HabEx (Habitable Exoplanet Observatory) to determine the potential of these telescopes to detect city lights not only on Proxima b, but also on planets orbiting stars out to a distance of 30pc (Parsecs. 1pc=3.26 light years). Both LUVOIR and HabEx have missions to catalogue and directly image exoplanets and are scheduled to launch in 2035.

Computer rendering of the LUVOIR Observatory – Credit NASA

Similar to Tabor and Loeb using a virtual JWST, Beatty pointed virtual LUVOIR and HabEx observatories at a number of star systems with known worlds like Proxima b as well as hypothetical Earth-like worlds orbiting G, K, and M class stars. Beatty also scaled the percentage of the planetary surface which was urbanized. The more urbanization, the brighter the planet’s nightside. The type of artificial illumination in this model simulates the most common lights on Earth – high pressure sodium street lights reflecting off concrete surfaces which also feature a spectrum distinguishable from natural starlight. So the variables are a) distance from Earth b) the planet’s level of urbanization, and c) the type of star the planet is orbiting. In each scenario, the virtual scopes are imaging planets for a minimum of 100 hours to collect enough light streaming through the void to resolve the target.

HabEx Observatory using its 52m floating starshade to block out unwanted starlight – Credit NASA

Blindingly Bright

Beatty (2021) Figure 5 See Description below – click to enlarge

The above figure from Beatty’s publication shows the trade offs between the distance from Earth, the level of urbanization, and the class of parent star. The first two variables, level of urbanization and distance from Earth, are self evident. The brighter the artificial lights, the easier they are to see. If the planet resides closer to Earth, its lights are easier to see. But the parent star also plays a role in visibility. Planets orbiting smaller, dimmer stars have better contrast. Their stars are faint enough to not overwhelm artificial illumination and so lower levels of urbanization can be seen on planets in M red dwarf star systems. The figure’s blue colour shade indicates the certainty of detection. 1 sigma (the Greek letter that’s denoted in the figure) is about 67% certainty. 3 sigma is closer to 99%. 10 sigma is virtually 100%.

However, while fainter stars provide better contrast for detecting artificial illumination, their habitable zone radius is very small. Planets orbit so closely to the star that if a given red dwarf is more than 10pc away, we can no longer distinguish its planets from the star. The operative term in the figure is called the IWA or “Inner Working Angle” at which the planet is now visibly too close to the parent star for city lights to be detectable at all. More distant targets would then favour brighter Sun-like stars (G yellow dwarfs (our Sun) and K orange dwarfs) with wider habitable zones where the planets orbit farther, and are more visibly distinguishable, from their stars.

But, in turn, those planets require a higher percentage of urbanization as their brighter parent stars create a less favourable contrast for the nightsides of those planets. Up to 10pc away, a planet with urbanization levels between 0.4 to 3% would have visible city lights if orbiting M stars while planets orbiting G/K stars would need upwards of 10%. Beyond 10pc only planets orbiting G/K stars have visible city lights but need even higher percentages of urbanization. The max range for any significant detection is around 30pc. The 4 scopes used in the figure are two versions of LUVOIR (A/B) and two versions of HabEx. LUVOIR A features a more powerful 15m mirror with LUVOIR B an 8m mirror. HabEx (SS) is the HabEx scope paired with a floating solar shade to filter starlight which aids in the detection of planets.

Ecumenopolis – A City Planet

This composite image, which has become a popular poster, shows a global view of Earth at night, compiled from over 400 satellite images. NASA researchers have used these images of nighttime lights to study weather around urban areas. Credit: NASA/NOAA – click to englarge

For all our own city lights, the Earth’s surface is only 0.05% urbanized. Our telescopes wouldn’t be able to see us were they parked at Proxima Centauri. A greater percentage of urbanization could help us see a distant civilization more clearly like say 100%. But…what exactly is 100% urbanization? An Ecumenopolis.

The glow of an Ecumenopolis world in the space strategy video game Stellaris Habitable planets in the game can evolve into these city worlds as your civilization develops over centuries in a simulated galaxy – Graphics from the video game Stellaris, developed and published by Paradox Interactive. Used with permission – click to enlarge

An Ecumenopolis is a city planet – a world where the entire surface is covered in one giant city. Several examples exist in science fiction such as the Human Empire Capital planet of Trantor in Isaac Asimov’s Foundation Trilogy, the Republic/Empire Capital of Coruscant in Star Wars, or the Ecumenopolis planet type in my favourite space strategy video game Stellaris (which I definitely played for inspiration while writing this article). But more than a geeky sci-fi concept, it’s conceivable that an advanced civilization could completely encase their world in an unending urban landscape. How visible would such a world be?

Figure 6 from Beatty’s article shows the distinct powerful glow of High Pressure Sodium Lights from an Ecumenopolis. These lights peak around the 600nm range in the highlighted area.

Beatty modelled the results and found that future telescopes would be capable of detecting Ecumenopolis worlds around 82 stars in the stellar neighbourhood of the Sun. That’s an astonishing amount of space. So if somebody out there is shining that brightly, we may be able to see them in the coming decade.

Proxima B-eacon

Beatty’s work demonstrates that close range red dwarf stars provide the best opportunity for detecting urban worlds meaning Proxima b is the current prime target. Detecting an Ecumenopolis version of Proxima b would be easy for next generation telescopes. In fact, we could detect just 0.5% urbanization on the planet. That’s still 10 times more than Earth’s present urbanization. However, current city growth rates put the Earth at 0.5% within the next hundred years – a blink in stellar time. If an alien civilization does exist, they could have already reached this level of urbanization assuming that technological civilizations are long lived. And that’s the thing – we don’t actually know that technological civilizations are long lived. That’s one of the reasons why we do SETI. Finding someone else shining in the void means there’s more hope that we can keep the lights on too.

Feature Image Description: Ecumenopolis Planet orbiting Proxima Centauri-like Red Dwarf Star – Graphics from the video game Stellaris, developed and published by Paradox Interactive. HUGE thanks to the Paradox Interactive and Stellaris team for allowing usage of their cool Ecumenopolis screenshots in this article. Build your own advanced civilization with Ring Worlds, Dyson Spheres, and Ecumenopolis planets by finding Stellaris on Steam.

More to Explore

[2105.08081] Detectability of Artificial Lights from Proxima b (arxiv.org)

[2105.09990] The Detectability of Nightside City Lights on Exoplanets (arxiv.org)

Stellaris Grand Strategy Science Fiction Video Game

James Webb Space Telescope – Webb/NASA

A Very Interesting Radio Signal was Just Detected Coming from Proxima Centauri – Universe Today

Habitable Exoplanet Observatory (HabEx) (nasa.gov)

LUVOIR (nasa.gov)

Potentially Habitable Exoplanet Confirmed Around Nearest Star! – Universe Today

The Color of Habitable Worlds – Universe Today

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Entertainment

Mark Wahlberg pays tribute to the late mom Alma on his 50th birthday

Post author By Mans Life Daily
Post date June 6, 2021

Mark Wahlberg remembers his late mother Alma Wahlberg on his 50th birthday.

The fighter star took to Instagram on June 5 to share a cute throwback photo of himself and his mother who died in April at the age of 78 after a battle with dementia. He titled the picture “Miss you”.

Mark’s followers sent love in the comment section. One wrote: “Forever in your heart!” Another added: “She was definitely an original!”

The actor, Alma’s youngest child, aged nine, previously shared an Instagram tribute to his mother shortly after her death. “My angel,” Mark wrote next to a photo of a smiling Alma. “Rest in peace.”

He also shared sweet news with his mother in May, during the first Mother’s Day the family celebrated without the matriarch. He posted a photo of himself, his wife Rhea Durham and Alma along with the caption: “Happy Mother’s Day. What would I be without these two. Miss you mom. Love you baby. To all mothers, thank you.”

Sport

NCAA baseball match 2021: Full regional league, TV schedule for the Highway to Faculty World Collection

Post author By Mans Life Daily
Post date June 6, 2021

For the first time in two years, the country’s best college baseball teams compete in the postseason to determine a winner of the Men’s College World Series.

The conference championships have been completed across the country and the top 16 teams have been selected by the NCAA. Now these 64 teams will compete in the Regionals, hoping for a chance to advance to the Super Regionals and get a spot in Omaha for the first time in two years.

Check out all the information you need to know about college baseball postseason.

MORE: Watch selected NCAA baseball games live with fuboTV (7-day free trial)

NCAA baseball tournament bracket 2021 bracket

The NCAA released the full baseball tournament series on Monday, including the 16 host locations and rankings of the nation’s best teams.

Arkansas leads the way as No. 1 in the group after hitting 46-10 and winning the SEC baseball tournament.

The teams will now go to the Regionals, where they will fight for the chance to advance to the Super Regionals. The top seeder in each bracket meets the No. 4 seeder, with the two middle teams playing against each other. A team has to get three wins in a regional league and everyone has to eliminate twice.

From there, the winner of the Fayetteville regional competition competes against regional winner No. 16, regional winner No. 2 against regional winner No. 15, and so on. Quarter-finals of the series.

Fayetteville

Arkansas (1)
Nebraska
Northeast
New Jersey engineering

Ruston

Louisiana Technology (16)
NC state
Alabama
driver

Austin

Texas (2)
State of Arizona
Fairfield
south

Gainesville

Florida (15)
Miami
South Alabama
South Florida

Knoxville

Tennessee (3)
duke
freedom
Wright State

Eugene

Oregon (14)
Gonzaga
State of Louisiana
Central State of Connecticut Central

Nashville

Vanderbilt (4)
Georgia Tech
State of Indiana
Presbyterian

Greenville

East Carolina (13)
Charlotte
Maryland
Norfolk State

Tucson

Arizona (5)
State of Oklahoma
UC Santa Barbara
Grand Canyon

Oxford

Old Miss (12)
Southern Mississippi
State of Florida
State in southeast Missouri

Fort Worth

TCU (6)
State of Oregon
Dallas Baptist
McNeese State

Columbia

Old Dominion (11)
South carolina
GRAPES
Jacksonville

Starkville

Mississippi State (7)
Virginia Commonwealth
Campbell
Samford

South curve

Notre Dame (10)
Connecticut
Michigan
Central Michigan

Lubbock

Texas Technology (8)
UCLA
UNC
army

Stanford

Stanford (9)
UC Irvine
Nevada
State of North Dakota

How to Watch NCAA Regional Baseball Games

All regional baseball matchups will be broadcast on ESPN networks June 4-7, before the Super Regionals run the following week.

Selected games can also be streamed live with fuboTV, which offers a free seven-day trial.

Here is the TV program of the Regionals:

Fayetteville Regional

Friday 4th June:
Game 1: No. 1 Arkansas 13, NJIT 8
Game 2: Nebraska 8, Northeast 6

Saturday 5th June:
Game 3: NJIT 3, Northeast 2 (Northeast eliminated)
Game 4: Arkansas vs. Nebraska, 9 p.m., ESPN3

Sunday June 6th:
Game 5: NJIT vs. Loser Game 4, 3pm
Game 6: Winner Game 4 vs. Winner Game 5, 9 p.m.

Monday June 7th (if required):
Game 7: Game 6 rematch

Ruston Regional

Friday 4th June:
Game 1: # 16 Louisiana Tech 18, driver 2
Game 2: NC State 8, Alabama 1

Saturday 5th June:
Game 3: Alabama 3, Driver 1 (driver eliminated)
Game 4: Louisiana Tech vs. NC State, 7 p.m., ACC Network

Sunday June 6th:
Game 5: Alabama vs. Loser Game 4, 3pm
Game 6: Winner Game 4 vs. Winner Game 5, 7 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 4 p.m.

Austin Regional

Friday 4th June:
Game 1: No. 2 Texas 11, South 0
Game 2: Arizona State 7, Fairfield 6

Saturday 5th June:
Game 3: Fairfield 6, Southern 2 (Southern eliminated)
Game 4: Texas vs. Arizona State, 9:10 p.m., Longhorn Network

Sunday June 6th:
Game 5: Fairfield vs. Losers Game 4, 2pm
Game 6: Winner Game 4 vs. Winner Game 5, 8 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 4 p.m.

Gainesville Regional

Friday 4th June:
Game 1: South Florida 5, No. 15 Florida 3
Game 2: Miami 1, South Alabama 0

Saturday 5th June:
Game 3: South Alabama 19, Florida 1 (Florida eliminated)
Game 4: South Florida 10, Miami 2

Sunday June 6th:
Game 5: South Alabama towards Miami, noon
Game 6: South Florida vs. Winner Game 5, 6 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6 at 1 p.m.

Knoxville Regional

Friday 4th June:
Game 1: No. 3 Tennessee 9, Wright State 8
Game 2: Liberty 11, Duke 6

Saturday 5th June:
Game 3: Duke 14, Wright State 6 (Wright State eliminated)
Game 4: Tennessee 9, Freedom 3

Sunday June 6th:
Game 5: Duke vs. Liberty, 2 p.m.
Game 6: Tennessee vs. Winner Game 5, 6 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6 at 1 p.m.

Eugene Regional

Friday 4th June:
Game 1: No. 14 Oregon 13, Central Connecticut State 10
Game 2: Gonzaga 3, LSU 0

Saturday 5th June:
Game 3: LSU 6, Central Connecticut State 5 (Central Connecticut eliminated)
Game 4: Oregon vs. Gonzaga, 10 p.m., ESPNU

Sunday June 6th:
Game 5: LSU vs. Loser Game 4, 6 p.m.
Game 6: Winner Game 4 vs. Winner Game 5, 10 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 10 p.m.

Nashville Regional

Friday 4th June:
Game 1: # 4 Vanderbilt 10, Presbyterian 2
Game 2: Georgia Tech 7, State of Indiana 6

Saturday 5th June:
Game 3: State of Indiana 9, Presbyterians 2 (Presbyterians eliminated)
Game 4: Vanderbilt 4, Georgia Tech 3

Sunday June 6th:
Game 5: Indiana State vs. Georgia Tech, 3 p.m.
Game 6: Vanderbilt vs. Winner Game 5, 9 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 7 p.m.

Greenville Regional

Friday 4th June:
Game 1: No. 13 East Carolina 8, Norfolk State 5
Game 2: Charlotte 13, Maryland 10

Saturday 5th June:
Game 3: Maryland 16, Norfolk State 0 (Norfolk State eliminated)
Game 4: East Carolina 7, Charlotte 5

Sunday June 6th:
Game 5: Maryland towards Charlotte, noon
Game 6: East Carolina vs. Winner Game 5, 6pm

Monday June 7th (if required):
Game 7: Game 6 rematch

Tucson Regional

Friday 4th June:
Game 1: # 5 Arizona 12, Grand Canyon 6
Game 2: UC Santa Barbara 14, State of Oklahoma 4

Saturday 5th June:
Game 3: Oklahoma State 5, Grand Canyon 3 (Grand Canyon eliminated)
Game 4: UC Santa Barbara v Arizona, 10 p.m. ESPN3

Sunday June 6th:
Game 5: Oklahoma State vs. Losers Game 4, 2pm
Game 6: Winner Game 4 vs. Winner Game 5, 8 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 8 p.m.

Oxford Regional

Friday 4th June:
Game 1: No. 12 Ole Miss 6, Southeast Missouri State 3
Game 2: Florida State 5, Southern Miss 2

Saturday 5th June:
Game 3: Southern Miss 21, Southeast Missouri 0 (Southeast Missouri eliminated)
Game 4: Ole Miss 4, Florida State 3

Sunday June 6th:
Game 5: Southern Miss vs. Florida State, 2 p.m.
Game 6: Be missed vs. Winner Game 5, 6 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 7 p.m.

Fort Worth Regional

Friday 4th June:
Game 1: No. 6 TCU 12, McNeese 4
Game 2: Dallas Baptist 6, Oregon State 5

Saturday 5th June:
Game 3: Oregon State 10, McNeese 5 (McNeese eliminated)
Game 4: Dallas Baptist 8, TCU 6

Sunday June 6th:
Game 5: Oregon State vs. TCU, 2 p.m.
Game 6: Dallas Baptist vs. Winner Game 5, 7pm

Monday June 7th (if required):
Game 7: Rematch of game 6, 4 p.m.

Columbia Regional

Friday 4th June:
Game 1: # 11 Old Dominion 4, Jacksonville 3
Game 2: South Carolina 4, Virginia 3

Saturday 5th June:
Game 3: Virginia 13, Jacksonville 8 (Jacksonville eliminated)
Game 4: Old Dominion 2, South Carolina 1

Sunday June 6th:
Game 5: Virginia vs. South Carolina, noon
Game 6: Old Dominion vs. Winner Game 5, 6pm

Monday June 7th (if required):
Game 7: Game 6 rematch

Starkville Regional

Friday 4th June:
Game 1: No. 7 Mississippi State 8, Samford 4
Game 2: VCU 19, Campbell 4

Saturday 5th June:
Game 3: Campbell 16, Samford 13 (Samford eliminated)
Game 4: Mississippi State vs. VCU, 8 p.m., ESPN3

Sunday June 6th:
Game 5: Campbell vs. Loser Game 4, 3pm
Game 6: Winner Game 4 vs. Winner Game 5, 8 p.m.

Monday June 7th (if required):
Game 7: Rematch of game 6, 4 p.m.

South Bend regional end

Friday 4th June:
Game 1: # 10 Notre Dame 10, Central Michigan 0
Game 2: UConn 6, Michigan 1

Saturday 5th June:
Game 3: Central Michigan 8, Michigan 2 (Michigan eliminated)
Game 4: Notre Dame 26, UConn 3

Sunday June 6th:
Game 5: Central Michigan vs. UConn, noon
Game 6: Our lady vs. Winner Game 5, 6 p.m.

Monday June 7th (if required):
Game 7: Game 6 rematch

Lubbock Regional

Friday 4th June:
Game 1: No. 8 Texas Tech 6, Army 3
Game 2: North Carolina 5, UCLA 4

Saturday 5th June:
Game 3: UCLA 13, Army 6 (Army eliminated)
Game 4: Texas Tech vs. North Carolina, 9 p.m., ESPN2

Sunday June 6th:
Game 5: UCLA vs. Losers Game 4, 3pm
Game 6: Winner Game 4 vs. Winner Game 5, 7 p.m.

Monday June 7th (if required):
Game 7: Game 6 rematch

Stanford Regional

Friday 4th June:
Game 1: No. 9 Stanford 9, North Dakota State 1
Game 2: UC Irvine 7, Nevada 0

Saturday 5th June:
Game 3: North Dakota State 6, Nevada 1 (Nevada eliminated)
Game 4: Stanford 12, UC Irvine 4

Sunday June 6th:
Game 5: State of North Dakota vs. UC Irvine, 4 p.m.
Game 6: Stanford vs. Winner Game 5, 9 p.m.

Monday June 7th (if required):
Game 7: Game 6 rematch

College World Series 2021 schedule

Regional: June 4th – June 7th
Super Regionals: 11.-14. June
CWS: 19.-30. June

According to the Regionals’ conclusions on June 7, teams have a few days before heading to the Super Regionals on June 11, where they will play in a best-of-three series to determine who will make it to the college quarter-finals World Series moves in.

Super Regionals are either hosted by the higher seed or placed on a neutral site. All College World Series games are played at TD Ameritrade Park in Omaha, Nebraska. The College World Series will be played through Wednesday June 30th.

Fixed matchups for games 5 and 6 in each region. Fort Worth and Columbia regional timetables have been added.

Health

Medline to promote majority stake to Blackstone, Carlyle and Hellman & Friedman

Post author By Mans Life Daily
Post date June 6, 2021

A worker at Medline Industries gathers exam gloves to include into Personal Protection Equipment (PPE) kits to be shipped out to various health facilities at their warehouse in Mundelein, Illinois, U.S., on Monday, Oct. 20, 2014. Photographer: Tim Boyle/Bloomberg via Getty Images

Bloomberg | Bloomberg | Getty Images

A group of private equity firms, including Blackstone Group, Carlyle Group and Hellman & Friedman, agreed to buy a majority stake in medical supply manufacturer and distributor Medline Industries, the company announced Saturday.

Medline, which had $17.5 billion in revenue last year, said it would use the investment to expand its product offerings and its business internationally.

It did not disclose the financial terms of the deal, which is expected to be completed in late 2021.

Earlier Saturday, The Wall Street Journal reported the parties were nearing a transaction that could value Medline at more than $30 billion, according to people familiar with the matter.

The Northfield, Illinois, company said it will continue to be led by the Mills family, who will remain its largest single shareholder. Its management team also will remain in place. Medline was founded in 1910 by A.L. Mills, and now distributes medical supplies to more than 125 countries, according to the company’s website.

“This investment from some of the world’s most experienced and successful private investment firms will enable us to accelerate that strategy while preserving the family-led culture that is core to our success,” said Charlie Mills, Medline CEO, in a release.

Science

Hawaii 5-Oy! – Watts with that?

Post author By Mans Life Daily
Post date June 6, 2021

From THE PIPELINE

In order not to be outdone by California and New York, policymakers in Hawaii are joining the long march towards unreliable power grids.

Clarice Feldmann writes:

Personally and on a small scale, I tend to like Big Thinkers. My beloved maternal grandfather was one of them. For example, he built a large boat in his little back yard and then found when he was finished that he had no way of getting it out of there until a friendly neighbor with the right equipment helped him pull down a fence and remove it . They towed the boat to Lake Michigan, where it immediately sank, overloaded as it was Grandpa’s hand-made metal-framed pictures of his ten grandchildren.

But you don’t want people like that in public who decide on public policy. I have often made fun of the Big Thinkers in California, whose grandiose plans for controlling the climate are absolutely impractical – the name for them is “Central Planner”. But California isn’t the only state that has placed great thinkers in public positions, and unless things change, the beautiful islands of Hawaii will soon be threatened by power outages.

Unless an energy law is changed, Hawaiians may move around in outrigger canoes instead of their electric vehicles, keep cool with hand fans, and work with sunlight and starlight. Hawaii was the first state to mandate a full transition to renewable energy when its then governor put that mandate into effect in 2015. By September next year, the law stipulates that 100 percent of electricity sales must come from renewable energies.

AES Hawaii, the state’s last coal-fired power station – it provides 15 to 20 percent of the islands’ electricity – is preparing to shut down to comply with the law. The planned replacement measures included the Kapolei Energy Storage Facility, which is to be built by the state’s largest electricity supplier, Hawaiian Electric. Like Grandpa’s boat in his back yard, this plan encounters a number of obstacles, most notably reality. “If there isn’t enough solar, wind, or battery storage to replace the AES, HECO would have to use oil instead to charge things like the upcoming 185-megawatt Kapolei energy storage facility,” reported Pacific Business News.

However, it is not a question of “if”. The reality is that there isn’t enough wind, solar or battery storage to replace the AES system. Hawaiian Electric has made this clear in recent documents, indicating that the company cannot meet its renewable energy target (75 percent) for the second year (75 percent) for “more than a decade”. That means Hawaii Electric will soon be recharging its huge battery to replace its soon-to-be-closed coal-fired power station … with oil. In other words, Hawaiians will trade one fossil fuel (coal) for another, albeit a much more expensive one.

This revelation prompted PUC chairman Jay Griffin to complain about Hawaiians “going from cigarettes to crack.” He said, “Oil prices don’t have to be much higher for this to look like the biggest spike people have seen. And it’s not acceptable. We have to do better. “

How exactly can you do better if I’m brave enough to ask?

Of course, it is silly to allow central planners to switch from an efficient, reliable, and cheaper way of generating electricity to a more expensive, unreliable way by the near date, but as certain central planning is always a mistake, it is from the central point of view The mistake always lies elsewhere for planners and their proponents. Much like Stalinists who blame engineers for not meeting production quotas and ignore the fact that they have been denied basic production supplies.

With the finger pointing at full speed:

For its part, Hawaiian Electric says some project delays are due to “a slow approval process of obtaining models and information from potential developers that is often beyond HECO’s control”.

Of course, the Hawaiian PUC points back at the company.

Jay Griffin, chairman of the Hawaiian Public Utilities Commission, pointed out the company’s lack of urgency and foresight, but acknowledged that “Each of these projects must go through numerous steps, including government approvals / permits and technical reviews of the connection to the Power grid”. Network before they can go online. These require coordination between a wide range of stakeholders, including the Commission. “

Read the full article here.

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Entertainment

Simon Guobadia responds to Falynn Guobadia’s teaser video – alleging fraud and being pregnant

Post author By Mans Life Daily
Post date June 5, 2021

Roommate, the situation of Simon Guobadia and Falynn Guobadia seems to be the tea that keeps spilling! On Thursday, Falynn announced that she would release an exclusive video telling the truth about her marriage to Simon and his most recent engagement to Porsha Williams. Well, it seems Simon wasn’t here for the Falynn’s announcement! Shortly thereafter, he posted her teaser video with a bold caption claiming she cheated on Falynn and a current pregnancy.

“The face of the deceitful woman,” wrote Simon in the caption of his post. “Let’s start with why I filed for divorce. Let’s start with who she cheated on and who is currently pregnant and living in a house I paid for – after the divorce. “

In the video clip shared by Falynn, she addressed previous allegations of fraud after the interview host, Adam Newell, raised the subject.

“Simon won’t get caught unless Simon wants to be caught,” Falynn replied.

Falynn continues, “I meant what I said when I made my vows.”

When asked if she had any resentments towards Porsha Williams, a woman who “met her family and swam in her pool,” Falynn could be seen fighting back tears.

“It hurts, it hurts like hell,” Falynn replied. “I love hard, I love really hard.”

However, according to Simon, he filed for divorce because Falynn allegedly cheated. In addition to calling Falynn, Simon tagged the man Falynn is said to be pregnant with in the caption of his post.

While Falynn has remained pretty calm about the situation, in addition to this teaser clip, she apparently had an additional reaction to Simon’s latest allegations. Falynn used her Instagram story to post a photo describing Narcissistic Personality Disorder’s behavior when dealing with criticism.

The man marked by Simon didn’t have much to say during the exchange on Thursday. He went to his Instagram story to close down a fake page created on his behalf. Fans also noted that a caption where both Simon and Falynn were tagged was edited to remove the tags.

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Science

One other Delay for Webb, However This Time it is Due to the Rocket, Not the Telescope

Post author By Mans Life Daily
Post date June 5, 2021

Officials from NASA and ESA this acknowledged the launch of the James Webb Space Telescope will very likely be delayed from the end of October to at least mid-November, 2021. As we reported last month, the usually reliable Ariane 5 has experienced problems on two previous launches where unexpected vehicle accelerations occurred when the fairing separated from the rocket. The fairing is the nose cone used to protect a spacecraft payload during launch and acceleration through Earth’s atmosphere.

“Indeed, there was an anomaly which has been mentioned recently in the media,” said Daniel de Chambure, acting head of Ariane 5 adaptations, during a media briefing on JWST. “The origin of the problem has been found; corrective actions have been taken.”

De Chambure added they are currently conducting the last tests and a qualification review has started “so we should be able to confirm all that in a few days or weeks. This should not jeopardize in any way the launch of James Webb,” he said.

Jeopardize, hopefully not. But delay, yes.

The officials in the briefing, including NASA’s Thomas Zurbuchen, NASA’s associate administrator for the Science Mission Directorate, were noncommittal about how long the delay may actually be.

The officials confirmed the telescope will be shipped to ESA’s launch site in Kourou, French Guiana in late August. From the start of shipping, it will take 10 weeks until the telescope will be ready to launch, with 55 days from its arrival to load the telescope on the rocket. When a member of the media worked out the timeline as leading to a launch no earlier than mid-November, Zurbuchen said that assessment is “approximately correct. I don’t really have anything else to add.”

He did add, however, that Arianespace and ESA has been transparent with information in the past ten months about the possible delays.

“We’ve had all the information that we need,” Zurbuchen said. We’ve had in-depth technical discussions with all parties aligned with one goal, and that is to create mission success.”

The James Webb Space Telescope inside a cleanroom at NASA’s Johnson Space Center in Houston. Credit: NASA/JSC

While the recent anomalies occurred during the past two Ariane 5 launches, the payloads were successfully placed in orbit, however. There are two Ariane launches on the manifest before the JWST launch, and those launches are now expected no earlier than June and August 2021, respectively.

While the JWST project has a well-known and well-documented history of significant schedule delays and project cost increases, recently the project has completed significant technical milestones, such as successfully completing the final set of acoustics and vibration testing in October 2020, and performing sunshield deployment exercises in December 2020. This spring, the primary mirror was opened for the last time on Earth before packing up the telescope for launch.

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Sport

UFC Spectator’s Information – The rebound battle has so much at stake for Jairzinho Rozenstruik, Augusto Sakai

Post author By Mans Life Daily
Post date June 5, 2021

After a rare weekend off, the UFC is back at its peak in Las Vegas on Saturday with a heavyweight competition between Jairzinho Rozenstruik and Augusto Sakai.

If we’re being honest, this UFC Fight Night provides some sort of replay for Rozenstruik (11-2) and Sakai (15-2-1) as they both get disappointing results at a UFC main event. Each of them had the chance to take a giant step forward in the division in their last fight – and each came up short.

The UFC Apex is hosting a Fight Night card titled by heavyweights eager to climb the rankings. Jairzinho Rozenstruik is looking to bounce back from losses in two of his last three fights, including one against current champion Francis Ngannou, while Augusto Sakai will be back in action after his first loss in his UFC career in September.

UFC Fight Night: Rozenstruik vs. Sakai
• Saturday, June 5th, 2021, UFC Apex, Las Vegas
• Primary Ticket: 7:00 PM ET on ESPN +
• Preliminary Round: 4:00 p.m. ET on ESPN +

Subscribe to ESPN + to get exclusive live UFC events, Cradles and more; Ariel and the villain; Dana Whites Contender Series; and more exclusive MMA content.

Rozenstruik, 33, in particular, was spectacularly lackluster in a five-round decision defeat to Ciryl Gane in February. Rozenstruik not only lost every single round of this main event; he never seemed to do much to turn the tide in his favor. He was shy and received a lot of criticism after the fight for this.

“I have to be the first in this fight,” Rozenstruik told the media this week, referring to the latest criticism. “No matter what’s going on, how it’s going to happen, I have to be the first. This fight will be exciting.”

For Sakai, 30, disappointment is less about his performance than about the outcome. After starting his UFC career 4-0, he stumbled on his biggest Test against Alistair Overeem last September. Sakai has shown promise and has many years ahead of him, but in his first main event, against an increase in the competition, he failed.

If any of these analyzes feel a little harsh – maybe too high expectations for Rozenstruik and Sakai – then that’s because it is meant to be. The UFC heavyweight division is wide, wide, wide open. It has a new champion in Francis Ngannou and a potential great addition in former light heavyweight champion Jon Jones. But it’s ripe for inclusion otherwise.

In all honesty, there are question marks with every other heavyweight contender. Former champion Stipe Miocic is looking for a comeback but is almost 40 years old. Derrick Lewis is on the run, but was previously neglected at the highest level. Gane has potential but is relatively inexperienced. Curtis Blaydes, Alexander Volkov, Shamil Abdurakhimov, Walt Harris – none of them stood out.

It is a gift for Rozenstruik and Sakai to account for this major event based on their respective losses. Who will benefit from it?

ESPN illustration

According to the numbers

5: Rozenstruik’s victories since the beginning of 2019, all by knockout. That ties him in with Ciryl Gane for most heavyweight wins and with Vicente Luque welterweight for the most placements in all UFC divisions during that period. Ten of Rozenstruik’s eleven career victories were achieved through KO / TKO.

2 relatives

11: Sakai knockouts in 15 career fights.

1: Aboriginal people of Suriname who participated in the UFC. Rozenstruik is the only one.

5.27 a.m.: Beats per minute in the Sakai UFC, the fourth most active heavyweight (at least five fights).

80: Percentage of takedown attempts by opponents successfully defended in the UFC by Rozenstruik, the second best among active heavyweights. Marcin Tybura, who fights at the Co-Main Event on Saturday, is in first place with 82.1%.

Sources: ESPN stats and information and UFC stats

Five against five

The latest results from Jairzinho Rozenstruik
Loss: Ciryl Gane (UD, Feb 27, 2021; watch on ESPN +)
Victory: Junior dos Santos (TKO2, August 15, 2020; watch on ESPN +)
Defeat: Francis Ngannou (KO1 May 9, 2020; watch on ESPN +)
Prize: Alistair Overeem (KO5, December 7, 2019; watch on ESPN +)
Victory: Andrei Arlovski (KO1, November 2, 2019; watch on ESPN +)

The latest results from Augusto Sakai
Loss: Alistair Overeem (TKO5 Sep 5, 2020; watch on ESPN +)
Prize: Blagoy Ivanov (SD, May 30, 2020; watch on ESPN +)
Victory: Marcin Tybura (KO1, September 14, 2019; watch on ESPN +)
Victory: Andrei Arlovski (SD, April 27, 2019; watch on ESPN +)
Victory: Chase Sherman (TKO3, September 22, 2018)

And the winner is …

Take part and win a FREE streaming of UFC 264! Make your selection

“I think the longer it takes, the more it favors Sakai,” said Cody Donovan, who coached the Elevation Fight Team to prepare fighters for both men. “I was impressed with Jairzinho fighting Alistair Overeem. I don’t think he did much for most of the fight. In round 4 I felt like he didn’t do anything Jairzinho did what he had to to do win. … When I’m Sakai’s coach, we turn up the volume, we move to the left, we stay away from Jairzinho’s left hand. We force the clinch, things that Sakai is pretty angry about. “

Watch Donovan and fellow coaches break down the main event and predict a winner.

How to see the fighting

Check out the fights on ESPN +. If you don’t have ESPN +, you can download it here. Also: Download the ESPN app | UhrESPN | Television program

There is also FightCenter which has live updates for every UFC card.

Battle card from Saturday Saturday

ESPN +, 7 p.m. ET
Jairzinho Rozenstruik versus Augusto Sakai | Heavyweight
Walt Harris vs. Marcin Tybura | Heavyweight
Roman Dolidze versus Laureano Staropoli | medium weight
Santiago Ponzinibbio versus Miguel Baeza | Welterweight
Dusko Todorovic versus Gregory Rodrigues | medium weight
Tom Breese versus Antonio Arroyo | medium weight
ESPN +, 4:00 p.m. ET
Montana De La Rosa vs. Ariane Lipski | Women’s flyweight
Tanner Boser vs. Ilir Latifi | Heavyweight
Francisco Trinaldo versus Muslim Salikhov | Welterweight
Makwan Amirkhani vs. Kamuela Kirk | Featherweight for men
Alan Patrick versus Mason Jones | Light
Manon Fiorot vs. Facebook Facebook logo Sign up on Facebook to meet up with Maryna Moroz. to join women’s flyweight
Sean Woodson vs. Youssef Zalal | Featherweight for men
Claudio Puelles vs. Jordan Leavitt | Light

Five More Things You Should Know (from ESPN Stats & Information)

1. The co-main event is like the heavyweight headlining match. Marcin Tybura has won four straight wins, the longest run in his UFC career. To keep it going, he has to get out of the way of Walt Harris early. Harris has the third fastest finish (12 seconds) in the history of the UFC heavyweight. He has a target rate of 100% (13 KO / TKOs) and the third shortest average fight time (6 minutes, 39 seconds) among active UFC heavyweights.

Alexander Volkanovski and Brian Ortega coach a dynamic cast of 16 rising athletes who have put everything else in their lives aside to pursue their UFC dreams. Season premieres on Tuesday June 1st. Watch on ESPN +

2. Roman Dolidze will try to continue the Georgian success story when he meets middleweight Laureano Staropoli. Fighters from the Republic of Georgia have been 15-2 in the UFC since the beginning of 2020.

3. LFA middleweight champion Gregory Rodrigues will make his UFC debut as a substitute for Dusko Todorovic. Rodrigues, who won an LFA title shot against Josh Fremd on May 21, appeared in Dana White’s Contender series in a 2020 loss to Jordan Williams. Todorovic was originally supposed to face Maki Pitolo.

4. Two fighters will jeopardize perfect records: Jordan Leavitt (8-0, 1-0 in UFC) starts the preliminary round with a light fight against Claudio Puelles and Miguel Baeza (10-0, 3-0 in UFC) is a veteran welterweight Santiago Ponzinibbio on the main card.

5. Saturday’s 28 fighters will represent 17 countries which, if the map was left intact, would set a record for most countries represented at a UFC event. The current record is 16, shared by three events.

ESPN’s Jeff Wagenheim contributed to this bout preview.

Health

Theranos is historical past, however large blood check breakthroughs are imminent

Post author By Mans Life Daily
Post date June 5, 2021

Medical researchers say that within a few years there will be major breakthroughs in blood testing technology that uses immune system response and genetic analysis to identify disease quickly and cheaply.

Image Alliance | Image Alliance | Getty Images

One morning in May last year, Tayah Fernandes’ mother, Shannon, found that her four-year-old daughter was seriously ill and took her to the nearest emergency room in Manchester, England. The coronavirus had crashed on Britain’s coasts weeks earlier, and emergency doctors were initially unsure how best to treat Tayah’s constellation of symptoms, which included abdominal pain and a bright red rash.

They gave her antibiotics for a suspected bacterial infection, but her condition only worsened, her fever rose. For her parents, for all parents, this was the ultimate medical nightmare; For days, doctors grope in the dark about the cause of their daughter’s illness.

Eventually, after further blood tests, doctors decided that Tayah had an unusual inflammatory syndrome that pediatric infectious disease specialists had just discovered, but which were believed to have links to Sars-COV-2.

Young patients across the UK and US arrived in intensive care units with symptoms similar to another disease that doctors have already recognized called Kawasaki. But they had no guarantee that the same treatment – injecting a solution of donor antibodies into the bloodstream – would be successful.

In Tayah’s case, the antibody solution known as immunoglobulin worked to provide relief to her parents. But around the same time last May, a team of researchers at Imperial College London, through complex analyzes of blood samples from patients like Tayah, confirmed that it was indeed a new disease, different from Kawasaki.

Hunt within the immune system’s response to bacteria, viruses

A related breakthrough in the same lab, specifically focused on individual gene behavior, could have seismic ramifications on a billion dollar diagnostics sector that has received unprecedented attention from patients, regulators, and the business community over the course of this pandemic.

A new way of identifying a particular disease from blood samples relies on the correlation between the activity of a small group of genes that make up the immune response and certain pathogens that cause a particular disease – just as the poliovirus causes polio, the coronavirus (SARS. ). -COV-2, a pathogen) causes Covid-19. Scientists believe that by examining a small number of genes, they can quickly identify what pathogen is in a patient’s system, what disease they have, and how best to treat them.

Companies, from small spin-offs from research universities to industry giants like Abbott Laboratories and Danaher’s Cepheid, want to build on two decades of research into how our own immune systems naturally react to foreign substances in our bodies, including pathogens like bacteria and viruses. A current technology like Cepheid’s GeneXpert technology is able to differentiate between the different RNA of different viruses like SARS-COV-2 or a certain strain of influenza, but experts are saying more and more clearly that our body’s immune system can be faster , more accurate detection systems.

In the past, doctors had to rely on a patient’s medical history and symptoms to narrow down the cause of a disease and develop a treatment plan. More recently, molecular-level laboratory studies like Cepheid technology have enabled clinicians to identify certain pathogens in nasal mucus, throat swabs, or blood samples that could have caused a disease. But searching for bacteria or viruses this way can be time-consuming, costly, and sometimes simply ineffective. The specific RNA signature of a virus can be difficult to identify.

Abbott and Cepheid did not respond to requests for comment.

More of CNBC’s healthy returns

The team at Imperial College, London, which works separately but simultaneously with several colleagues around the world, is now convinced that future diagnoses can soon be carried out with table tests that will only take a few minutes.

These tests would not look explicitly for a specific pathogen, but instead would allow scientists and medical professionals to simply observe how certain genes behave in the body, as an indication of how an immune system is already reacting to a pathogen that may otherwise not be easily recognized is more detectable.

Imperial College Professor Mike Levin is currently leading an ongoing European Union funded study entitled “Diamonds” that focuses on this potential. In recent years he and other scientists have shown how the observed activity in a small number of our genes can function as a kind of shortcut for our body’s immune response to a pathogen. When a handful of certain genes out of the thousands in a blood sample are activated – or, on the contrary, inhibited – it can indicate that a person is preparing to fight off a particular pathogen.

We think this is a completely revolutionary way of medical diagnosis.

Imperial College Professor Mike Levin

Levin and colleagues already have a proof of concept for this diagnostic approach after studying thousands of patients with tuberculosis fever and hundreds of Kawasaki patients. And his Imperial College team’s work on the Diamonds study is starting to bear fruit and could help identify the diverse immunological markers of diseases such as coronavirus-related multisystem inflammatory syndrome in children like Tayah Fernandes, now commonly known as MIS -C. To identify.

When Covid-19 surfaced in multiple locations, with MIS-C in its wake, it provided Levin and his researchers with an unprecedented opportunity to test this technique on an entirely new disease.

In the future, these tests – by relying on huge amounts of data and machine learning – should be able to produce multi-class, rather than just binary, results. This not only enables them to determine whether a pathogen is bacterial or viral, or whether or not someone has a certain disease, but also to distinguish which of a variety of diseases affects their patients.

In short, Levin expects that by studying the behavior of a relatively small number of genes, clinicians will be able to assign patients to all major disease classes within an hour.

“We think this is a completely revolutionary way of medical diagnosis,” said Levin. He expects research to provide the basis for new technologies, but has no financial interest in any related business.

Rather than what he calls the “step-by-step process” of first clearing bacterial infections, treating the most common conditions, and then doing further research, “this idea is the very first blood test that can tell you whether the patient has an infection or not “. an infection, and which infection group it is, down to the individual pathogens. “

Purvesh Khatri, Associate Professor at the Stanford Institute for Immunity, Transplantation and Infection and Department of Medicine, says that our immune systems have been evolving for millennia to fight pathogens, and therefore, it could prove to be more effective and efficient in the response of our bodies .

“We didn’t have a technology that could measure a number of genes quickly at the point of care,” he said. “But there has been enough technology in the last few years that we can now measure some genes in a rapid multiplex point-of-care assay.”

Although neither the FDA nor any European regulator has approved these type of gene-based pathogen detection systems, Khatri, who is helping set up a related commercial company, says they are coming soon. “There will be more than one coming out in the next year or two.”

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