Categories
Science

These new pc simulations of the solar are hypnotic

It is almost impossible to overemphasize a star’s primal, raging, natural power. Our Sun may seem harmless in simple observations, but with the advanced scientific tools at our disposal today, we know otherwise. When observed outside the narrow band of light our eyes can see, the Sun appears as an angry ball, occasionally hurling huge jets of plasma into space, some of which crash into Earth.

Plasma jets hitting the ground isn’t something to celebrate (unless you belong to some weird cult). it can cause all sorts of problems.

Some scientists devote themselves to studying the sun, in part because of the danger it poses. It would be nice to know when the sun throws a tantrum and if we’re in its way. We have several spaceships dedicated to detailed exploration of the sun. The Solar Dynamics Observatory (SDO), the Solar and Heliospheric Observatory (SOHO), and the Parker Solar Probe are all engaged in solar observations.

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The Solar Dynamics Observatory (l), the Solar and Heliospheric Observatory (m) and the Parker Solar Probe (r.) Credit: Left: NASA. Middle: By Cgruda – http://sohowww.nascom.nasa.gov/gallery/images/SOHOLower2.htmlFile:SOHO nasa.tif, Public Domain, https://commons.wikimedia.org/w/index.php?curid =28983655. Right: NASA

The Sun’s powerful magnetic fields play a big part in the solar flares, though scientists are still working on the details. A new study published in Nature Astronomy is helping scientists understand magnetic fields in more detail. It is titled “Numerical evidence for a small dynamo approaching the solar-magnetic Prandtl numbers,” and the first author is Jörn Warnecke, a senior postdoctoral researcher at the Max Planck Institute for Solar System Research (MPS).

The solar dynamo is responsible for the sun’s magnetic fields. The solar dynamo consists of two parts: the small dynamo and the large dynamo. The problem is that solar researchers have not yet been able to model them, at least not in great detail. Trouble is, they can’t confirm that a small-scale dynamo (SSD), which is ubiquitous in astrophysical bodies across the Universe, can even be generated by conditions in the Sun. This is obviously a big problem, because a small dynamo would have a big impact on how the sun behaves.

“A powerful SSD can potentially have a major impact on the dynamic processes in the sun,” the authors write in their article. “Therefore, it is of great importance to clarify whether an SSD can exist in the Sun or not.”

What is a small dynamo?

According to this study, a small dynamo amplifies magnetic fields at magnitudes smaller than the magnitude driving turbulence in various astrophysical media. It’s easy to go astray trying to understand this in detail. But in very simple terms, an SSD requires much more turbulence than a large dynamo.

It all depends on what is called a Prandtl number (PrN,) and what the Prandtl number of the sun tells us about its properties. The Sun’s PrN tells us how quickly its magnetic field fluctuations and speed even out. The Sun has a low PrN, and scientists studying the Sun have long thought that the low value prevented the development of an SSD.

But this research shows otherwise. It is based on extensive computer simulations on petascale supercomputers in Finland and Germany.

This figure from the study is a visualization of the flow and the SSD solution. Flow velocity is on the left, magnetic field strength on the right. This simulation run showed a very low Prandt number. “As expected in low PrM turbulence, the flow exhibits much finer, fractal-like structures than the magnetic field,” the authors explain. Image source: Warnecke et al. 2023

“Using one of the largest possible computer simulations currently available, we have achieved the most realistic environment for modeling this dynamo to date,” says Maarit Korpi-Lagg, group leader in astroinformatics and associate professor in the Computer Science Department at Aalto University. “We have not only shown that the small dynamo exists, but also that the more our model resembles the sun, the more practical it becomes.”

Low values ​​for the Prandtl number mean that the plasma velocity and the magnetic field fluctuation in the sun quickly balance out. And the faster they equalize, the less likely it is that an SSD can form. By finding that this is not the case, and that conditions on the Sun can produce an SSD, scientists’ understanding of the Sun, its magnetic fields, and its plasma ejecta only increases. And that’s good for us, living on a planet that’s right in the path of some solar ejection.

Coronal Mass Ejections (CME) observed by the Solar Dynamics Observatory on June 7, 2011. CMEs eject plasma from the Sun’s corona. Image Credit: NASA/SDO

“This is a big step towards understanding the magnetic field generation in the Sun and other stars,” says Jörn Warnecke, senior postdoc at the MPS. “This result will bring us closer to solving the mystery of CME formation, which is important to protect Earth from dangerous space weather.”

As many Universe Today readers know, the Sun follows an 11-year cycle that determines its magnetic fields. Every 11 years, the sun’s poles switch places, and that changes the sun’s behavior. Flares, solar flares, and coronal mass ejections increase in mid-cycle, known as Solar Maximum. Because solar flares can disrupt communications, power grids, and other infrastructure on Earth, scientists want to better understand it.

This image represents a current 11-year solar cycle and shows the Sun in ultraviolet light. The solar maximum is in the middle of the cycle, when the sun shows significantly more activity. Photo Credit: Dan Seaton/European Space Agency (Collage by NOAA/JPL-Caltech)

The interactions between SSD and LSD create the solar cycle, so these findings help to better understand solar weather and when to expect chaos to come.

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Entertainment

DC Younger Fly associate spouse Jacky Oh dies aged 32

The Shade Room is sad to announce this Mrs Jacky OhBirth Name Jacklyn Smithpassed away at the age of 32. Jacky was a longtime love partner of a comedian and actor DC Young Fly.

MTV’s “Wild ‘N Out” confirmed the tragic news on Thursday (June 1) on its verified Facebook page. The full statement states:

“We are deeply saddened by the passing of Jacklyn Smith, known to the world as Jacky Oh, a talented member of the Wild N’ Out family whose influence will be forever appreciated and missed. Jacky Oh was a loving friend and beloved colleague of the Wild N’ Out cast for five seasons. More importantly, she was an amazing mother to three wonderful children. BET Media Group sends our sincere condolences to the Smith family, DC Young Fly, B Simone, Nick Cannon and all the friends who loved and cared for Jacky Oh during this difficult time.” – A spokesman for BET Media Group “

The pair reportedly met in 2015 while Jacky was working on Wild ‘N Out. Since the beginning of their relationship, DC and the now beautiful entrepreneur have had three children – all under the age of 10. They have two daughters nova And Nala, and a son named Prince, who was born in 2022.

RELATED: Grandmother of 11 dies after BBL surgery, doctor fined $10,000

At this time, her family has not confirmed Jacky’s cause of death.

Sources who have allegedly spoken to TMZ and cosmetic surgery gossip blog, Surgeon Made Curves, said the influencer was seeing Dr. Zachary Okhah been to Miami.

Following the Instagram feed post, Surgeon Made Curves released another statement regarding Jacky’s death on his Insta story.

“As much as we’d all like to believe this is one big lie…it’s been 100% confirmed,” the post reads.

A source revealed to The Shade Room that DC Young Fly received the news while he was signing up for Wild ‘N Out in Atlanta and production on the show was subsequently halted. However, he has not publicly responded to reports of Jacky’s death.

After receiving official confirmation from someone close to the family, we’re republishing the post.

As we previously reported, MsJackyOh was with Dr

— The Cosmetic Lane (@TheCosmeticLane) June 1, 2023

Last month, Mrs Jacky Oh shared the results of a Mother’s Day photoshoot, celebrating her role as a mom.

“I do a lot. But being a mom is my favorite. God chose me three times. I promise I’ll never take it for granted. I’m so fucking blessed man! Happy Mother’s Day mommy :)” she read caption.

This is an evolving story. Check back for updates.

Categories
Sport

A automobile journey and a Sport 7 loss that activated Nikola Jokic into an MVP

  • Ramona Shelburne, ESPN Senior WriterJun 1, 2023, 08:00 AM ET

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    • Senior writer for ESPN.com
    • Spent seven years at the Los Angeles Daily News

IT WAS A suggestion at first. The kind of thing a friend brings up during a long car ride when there will be plenty of time to discuss it. And in the winter of 2019, Denver Nuggets strength and conditioning coach Felipe Eichenberger had his pick of long car rides to the airport with star center Nikola Jokic to choose from.

The two had grown close in the four years they’d worked together. Eichenberger spent a month with Jokic in the big man’s native Serbia each offseason. Jokic was present when Eichenberger’s daughter was born — and for all of her birthday parties afterward. Before games, Jokic often went into Eichenberger’s office to escape the noise of the locker room.

Jokic had started talking with his friend and training coach about getting in better shape. He would text Eichenberger a bodybuilding video and would then joke he wanted to look like that someday. Or he’d mention that his knees or back hurt after games and would ask Eichenberger if losing weight might help with that.

For years, Jokic had been told by coaches, executives and talking heads in the media that he needed to get in better condition if he wanted to succeed in the NBA. But now it was coming from within.

It was time for Jokic to hear this.

“You can be MVP in this league,” Eichenberger told him.

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Jokic had just been named to his first All-Star team. He had won a Player of the Week award in early February. The Nuggets were in first place in their division. Everything was trending upward. Which meant it was time to start pushing Jokic to an uncomfortable place: superstardom.

“He got mad at me,” Eichenberger says, laughing at the memory. “He got pretty heated. He’s like, ‘That’s not the player I am. I pass more than I score. … I’m not selfish.'”

For those who know Jokic, who will be playing in his first NBA Finals against the Miami Heat beginning with Thursday’s Game 1 (8:30 p.m. ET, ABC), this was not an unexpected response.

“I never coached Tim Duncan, but I always compare him to Tim Duncan,” Nuggets coach Michael Malone tells ESPN. “He’s just a selfless superstar who’s almost embarrassed by the attention.

“He’s not beating his chest, saying, ‘Look at me.’ He’s saying, ‘Hey, look at us. This is a group.'”

Eichenberger knew going into the conversation he might touch a nerve. But that was the point. And the ride to the Denver airport was at least 25 miles. So he dove in further.

“I knew he wanted to work,” Eichenberger says. “He was always willing to work.”

So rather than try to untangle the self-consciousness that the MVP talk was triggering, Eichenberger laid out a plan for Jokic to transform his body.

Focus on the work, not what it means to be an MVP.

Jokic thought about it for a little bit before answering.

“OK,” he said. “Let’s do it.”

After every game, no matter how many minutes he played, they’d lift weights. He would change his diet, cutting out as many indulgences as possible, which meant no soda, no beer, no snacks while he played video games.

An exception was made for orange juice and the occasional bite of his mother’s cooking, when she visited from Serbia. But just a bite. “I actually told him to enjoy his mom’s food after games,” Eichenberger says. “Like, come on, you can’t not eat your mother’s cooking.”

“But once he gets something in his head,” Eichenberger adds, “that’s how it’s going to be.”

OVER THE REST of that 2018-19 season, Jokic adhered to this routine religiously, even lifting after playing 64 minutes in a four-overtime loss to the Portland Trail Blazers in Game 3 of their Western Conference semifinal series.

Denver ended up falling to Portland in seven games, and while Jokic led the team in every category — averaging 27.1 points and 13.9 rebounds in 42 minutes a game — he had worn down as the series went on.

By the end of Game 7, he had nothing left. He missed seven of 10 shots in the fourth quarter, unable to carry his team across the finish line.

It was a devastating defeat. The Nuggets had been up by 11 points at home midway through the third quarter. All they had to do was finish and they’d be in the Western Conference finals against a Golden State Warriors team that was dealing with injuries and chemistry issues.

Afterward, as Malone huddled the Nuggets coaches in the locker room, they heard a knock at the door.

It was Jokic. He had come to tell them he’d never let that happen again.

David Adelman remembers the sentiment in Jokic’s voice as much as what he said.

“He was emotional when he came in,” said Adelman, the lead offensive assistant coach for the Nuggets. “I think he felt like he wore down in the second half, and we all looked at him like, ‘Joker. You carried us through this whole process.’

“The responsibility he has for us is different than maybe any player in the NBA. He can be our center. He can be our point guard. He can play the wing. He can be a catch-and-shoot guy. He’s playing every part of the floor.”

But Jokic was not interested in any consolations. He had finally felt what he and Eichenberger had been talking about: Everything he had was not enough to win. There was another level he needed to get to.

“I mean, he gave everything he had possible,” Adelman said. “But then I think he, in his mind, thought, ‘Maybe I can give more. Maybe if I get in even better shape. Maybe if I do this.'”

And so he did.

Nikola Jokic, seen here playing against LeBron James and the Cavaliers in March 2017, had a different body makeup than what he has now entering the 2023 NBA Finals. Chris Humphreys/USA TODAY Sports

BY THE TIME Jokic returned to training camp in fall 2019, the change in his physique was striking. He was leaner and stronger, having lost 20 to 30 pounds while gaining muscle everywhere. The effect of this change became immediate on the court. Jokic played in every regular-season and playoff game, finishing ninth in MVP voting and leading Denver to the Western Conference finals in 2020.

“He lost 10 pounds, and he’s like, ‘It feels good.’ He lost 20 pounds, and he’s like, ‘Wow. I can dunk now?'” Eichenberger said. “He lost 30 pounds. Like, ‘Wow. I can really sprint.'”

During the four-month shutdown because of the COVID-19 pandemic, Jokic kept training and eating healthily. So much so that photos of him taken at a gym in Serbia went viral on social media.

Was that Jokic or tennis player Novak Djokovic?

Former teammate Jameer Nelson texted Jokic immediately after seeing the photos.

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“When you do something like that, you deliver a message to your teammates,” Nelson told ESPN. “When you do something for your body or your mind like he did, the way he did it, everybody gets stronger.”

Nelson, a 2004 first-round pick and 2009 All-Star, had played with Jokic in Denver from 2015 to 2018, and like most people who knew Jokic early in his career, he cannot say he saw this kind of transformation coming.

“His skill level was high,” Nelson said. “But obviously, I didn’t know he’d be an MVP.”

At the beginning of Jokic’s rookie season in 2015, Nelson had organized a voluntary camp for the team near his home in suburban Philadelphia right before training camp.

He put guys up at the local Marriott hotel, put them through his offseason conditioning workouts at a local gym, then organized paintball and golf outings during their free time. Jokic was just looking to make an impression and, hopefully, the roster that fall.

There were no coaches there. But toward the end of the week, then-Nuggets general manager Tim Connelly called Nelson to check in.

“Who looks the best?” Connelly asked Nelson.

“The foreign kid,” Nelson told him. “I don’t really know his name, but once he learns English and gets in better shape, he’s going to be really good.”

JUSUF NURKIC WAS one of the only people who knew anything about Jokic when he came to Nelson’s camp that fall. They’d played against each other in the Adriatic league as teenagers.

But whereas Nurkic, the Bosnian center, had been invited to the green room in New York as a projected first-round pick in 2014, Jokic was asleep back in Serbia when his name was finally called late in the second round, while the broadcast was airing a Taco Bell commercial.

“He played exactly the same style as he does now,” Nurkic told ESPN. “But it was a different type of basketball. The pace was totally different. So I don’t think people could really see what he could be.”

Jokic is pictured playing against his former teammate Jusuf Nurkic in March 2017 at Portland. Sam Forencich/NBAE via Getty Images

It is important to remember this about Jokic’s background when you hear him talk now. He’ll say he never expected to make it to the NBA, much less win two MVP awards, and people assume he is just being modest.

But this is not an act. He’s just modest.

You notice it as he covers his mouth when he has to talk about himself publicly. Or in his self-deprecating jokes about his English or always being a bit off-balance on the court.

On Saturday, prior to the 2023 NBA Finals, he was asked when he realized it might be possible for him to win an MVP award one day and whether it was true Eichenberger had planted that seed.

“I mean, still isn’t,” he said with a shrug. “But yeah, that’s true. Felipe was the first guy who told me I was going to be an MVP. It was a car drive to the airport. I remember … I was laughing.

“To be honest, I’m playing the same way since my days in Sombor [Serbia]. I didn’t change. Maybe I upgrade a little bit, but I didn’t trade my style or play since day one.”

Jokic is underselling himself. Of course he has upgraded since coming to the NBA. He has transformed his body from a chubby, soda-guzzling teenager into a fit, 28-year-old, triple-double generator.

“He’s an ultra-conditioned athlete now,” Malone said after the Nuggets beat the Los Angeles Lakers in the Western Conference finals. “The guy can play for minutes on top of minutes and play at a high level.

“He made that turn. And his dedication from that point on has allowed him to become a two-time MVP.”

THE NIGHT THE Nuggets swept the Lakers to advance to the NBA Finals was supposed to feel like a culmination of everything Denver had been through. For the faith the Nuggets had shown in their core of Jokic, Jamal Murray and Michael Porter Jr. over the previous five years. For the patience they’ve had through significant injuries and setbacks. For the vision they’d had in drafting those players in the first place and the way they’ve built around them since.

But Jokic found himself strangely unsatisfied and restless during the long break they had until the start of the Finals.

Thursday
Game 1: Heat at Nuggets, 8:30 p.m.

Sunday
Game 2: Heat at Nuggets, 8 p.m.

Wednesday, June 7
Game 3: Nuggets at Heat, 8:30 p.m.

Friday, June 9
Game 4: Nuggets at Heat, 8:30 p.m.

*All times Eastern

More: Playoff schedule, news, more

“To be honest … I thought it was going to be a much bigger feeling,” he said on Saturday. “Yes, we won the game, and I was really happy. Yes, we made history. This, that. But next year, nobody is going to remember us. Maybe if we win it all, maybe it’s going to be different.”

Adelman is not surprised to hear Jokic in such a reflective mood. Over the six seasons he has coached him, there have been many conversations like this.

After the team lost its final regular-season game in 2018 at the Minnesota Timberwolves, Adelman remembers Jokic coming to the back of the team plane and sitting with the coaches to discuss the campaign and where the team could go from there.

“He really takes stock and ownership of what he just experienced, and he likes to talk it out,” Adelman said. “I think that’s why we’ve grown steadily as a group, is having a person that’s your leader who thinks that way.”

Jokic did this before he was a leader too.

He even did it as a rookie, when it became clear his presence had disrupted Nurkic’s development.

Nurkic had been a friend and a mentor to Jokic, helping him acclimate to life in the NBA and America. But there wasn’t room for both of them in the starting lineup, and within a few months, it was clear Jokic was the team’s center of the future.

There were no hard feelings, Nurkic said. He just wanted to be somewhere he could start, so he asked for a trade. Jokic understood, but he didn’t think it had to come to that.

“He went to the coaches and offered to come off the bench,” Nelson said. “Like he really didn’t care about starting. It didn’t matter to him. He just wanted everybody to be happy.”

Nurkic said he never knew Jokic offered his starting spot back then. He just knew his friend wanted him to stay and believed they could play together.

“We still talk about what could have been,” Nurkic said. “But everything happens for a reason. I’m happy with my career. And I’m happy for him too … His story is really amazing.”

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1:24

Mike Malone on facing Heat: ‘Forget the 8th-seed stuff’

Mike Malone says the Denver Nuggets will face the “biggest challenge of their lives” against the Miami Heat in the NBA Finals.

FOR THE MOST part, Jokic lets others tell his story. Coaches, former teammates, friends.

“I think probably my family, my close friends … you need to ask them,” Jokic said, when asked whether he has changed since the spotlight started shining on him. “But they are not going to answer you.”

He is aware that this is a funny answer because people in the room laughed afterward. But he also has to know he isn’t giving the most satisfying answer to an audience that is accustomed to superstars delivering those lines.

It’s hard to know what to do with someone who doesn’t bask in the attention the NBA spotlight creates.

But that’s not his problem to solve.

The night he was named the MVP of the Western Conference finals, the story was LeBron James talking postgame about possible retirement.

But if Jokic had a reaction to James stealing his thunder, nobody heard it. He reads books, not his mentions, having deleted all his social media years ago.

“Maybe someone should actually start to address that, like, being humble is a virtue,” Nuggets assistant coach Ognjen Stojakovic told ESPN. “That it’s OK to be humble, be a hard worker, be a good person.”

Stojakovic has known Jokic since he was a teenager making his way through the Adriatic league. He knows where Jokic is from in Serbia. He visits him in the summers.

He knows Jokic’s parents and his two older brothers. And now he knows Jokic’s wife and daughter.

“Honestly, it’s very fun to be part of his journey,” Stojakovic said. “To see how he’s maturing from year one to year two, three, four, five, six, seven.

“You know he came as a boy. Now he’s a father.”

Each step was deliberate and thoughtful. This last one will be the hardest.

“For the first two years, we butted our heads because he had his own pace and he didn’t understand how hard he had to work,” Stojakovic said. “But now he does. He works so hard. And he’s ready to do whatever it takes to win.”

Categories
Health

FDA contemplating abroad chemotherapy imports

WINDSOR, ON – MAY 8: Pharmacy technician by training, Dawn Deslippe, carefully labels Diane’s dose of carboplatin, one of two chemo medications she will be given at this visit. Each step of the process requires verification by at least two people. The hospital now makes the chemo drugs themselves instead of having them pre-mixed. Diane Marley, 48, is a cancer patient at Windsor Regional Hospital. She was diagnosed with breast cancer in December. She will finish her chemotherapy in the next few weeks. She is one of hundreds of Ontario cancer patients who have received diluted chemotherapy in the last year and are still undergoing treatment to fight the disease. (Richard Lautens/Toronto Star via Getty Images)

Richard Lautens Toronto Star | Getty Images

The Food and Drug Administration — which is facing nationwide shortages of more than a dozen cancer drugs — is considering allowing temporary imports of chemotherapy drugs from foreign manufacturers that are not currently approved for distribution in the United States, a spokesman for the agency said to CNBC.

The FDA has not said which manufacturers would be potential candidates to allow temporary importation of these drugs until approved manufacturers are able to meet patient needs.

But “in these cases, we check the quality of the foreign product very carefully and make sure it’s safe for US patients,” the spokesman said.

The FDA has taken similar action in the past to ease import restrictions amid drug shortages. In the summer of 2022, the FDA allowed the import of baby formula from non-regulated manufacturers when there was a severe infant formula shortage in the United States

The American Society of Clinical Oncology expects shortages to continue through June, but will then ease, especially when the FDA lifts import restrictions, according to Dr. Julie Gralow, the chief physician of this group.

“We hope and expect to have a more stable supply by the end of next month,” Gralow said.

At least 14 cancer drugs are currently in short supply in the US

But doctors in hospitals across the country say the situation is particularly acute with two drugs — cisplatin and carboplatin — because they’re so important and widely used in cancer treatment.

The World Health Organization has stated that cisplatin and carboplatin are essential for basic health care.

Intas Pharmaceuticals, one of the largest manufacturers of these drugs, has temporarily halted production and it is not clear when the company will resume production.

According to the National Cancer Institute, up to 20% of cancer patients require platinum-based chemotherapy drugs such as cisplatin and carboplatin for treatment.

And more than 100,000 Americans will be diagnosed in 2022 with cancer treatable with carboplatin or cisplatin, generic drugs that have been on the market for decades, the American Society of Clinical Oncology says.

These drugs are used to treat a variety of diseases, including testicular, ovarian, breast, lung, bladder, and head and neck cancer.

Drug shortages have forced some hospitals to ration drugs, reducing doses to expand their supplies and prioritizing patients who would benefit most from treatment.

Some cancer patients could die if the shortage isn’t fixed quickly, doctors said.

“Legislators in the country need to understand that this is a big problem at this point. If nothing changes in the next few weeks, it could create a major national emergency from a patient and healthcare perspective,” said Dr. Abdul Rafeh Naqash, a physician at the University of Oklahoma’s Stephenson Cancer Center.

Naqash said his facility was close to running out of carboplatin. He said the shortages are a national security issue that must be addressed quickly.

“It’s getting worse locally. Something has to happen and change immediately,” said Naqash, who specializes in lung cancer.

He said he recently had to tell a patient that he would not receive carboplatin due to the deficiency.

Such talks are likely to occur more frequently in the coming weeks barring relief, Naqash said.

Naqash said he doesn’t understand why the US doesn’t have a nationwide stockpile of these drugs to fill the gap in emergency situations.

Philip Schwieterman, director of oncology and infusion services at the University of Kentucky Health System, said, “If I go to the grocery store and I want a kiwi, they usually have kiwis.”

“It baffles me that if I want some cisplatin, even though it saves lives, I can’t get cisplatin,” Schwieterman said.

“A cascading drug shortage”

The shortages of cisplatin and carboplatin are due to the temporary closure of production for the US market at a plant in India operated by Intas Pharmaceuticals.

Intas decided to halt production after an FDA inspection late last year found a “cascade of errors” in the plant’s quality control unit.

Headquartered in Ahmedabad, India, Intas distributes cisplatin and carboplatin in the United States through its subsidiary Accord Healthcare.

When cisplatin shortages began in February, many patients switched to carboplatin, which is considered a sister drug, said Marc Phillips, who leads the in-patient pharmacy supply chain for WVU Medicine, West Virginia’s largest health care system.

That shift has “resulted in what we think are cascading drug shortages,” Phillips said.

“One deficiency has now caused another,” he said.

Fresenius Kabi, Hikma Pharmaceuticals, Teva and Pfizer make the drugs, but these companies have not been able to keep up with demand since the Intas plant shut down.

Intas is working with the FDA on a plan to resume production.

However, a date has not yet been confirmed, said company spokeswoman Emily King.

When the plant restarts, production will prioritize drugs based on medical need, King said.

She noted that FDA’s drug shortage staff and Office of Compliance have identified carboplatin and cisplatin as medical necessity for the US market.

The FDA spokesman said Intas has begun releasing doses of cisplatin and carboplatin into the United States that were previously on hold pending a testing and verification process.

Ensuring the production of cancer treatments continues

dr Karen Knudsen, CEO of the American Cancer Society, said the shortages highlight a long-standing economic problem in the generic drug market.

Manufacturers are reluctant to invest more money in making low-cost drugs like cisplatin and carboplatin, making them vulnerable to shortages if a factory goes down, Knudsen said.

Knudsen worries that unless the federal government and industry work together to solve the problem, the US will fall into a vicious cycle of cancer drug shortages.

“We need financially viable manufacturing to make effective and affordable cancer therapies,” she said.

Knudsen said demand for these drugs will increase in the coming years as the population ages, as older people face a higher risk of cancer.

And drugs like carboplatin and cisplatin use precious metals — platinum — mostly sourced in South Africa and Russia.

The World Platinum Investment Council is forecasting a large deficit in the precious metal this year, due in part to disruptions in South Africa due to power shortages and operational problems in Russia due to sanctions over Ukraine’s Kremlin invasion.

Drug manufacturers are required to notify the FDA of production stoppages six months in advance or as soon as they are able. Knudsen said the early warning system does not appear to be working effectively.

“The fact that we’re sitting here right now talking about this cancer shortage tells us that either the early warning system wasn’t activated soon enough or there aren’t enough manufacturers to address the supply chain problem,” she said.

The FDA is working with the company to increase supply to meet patient demand, the agency’s spokesman said.

A trio of Democratic lawmakers from Michigan, Sen. Debbie Stabenow and Gary Peters, Rep. Elissa Slotkin, wrote in a letter last month calling on FDA Commissioner Dr. Robert Califf to “use all existing authorities to mitigate this serious deficiency”.

The letter said Congress was working on long-term solutions to the drug shortage that has been a problem for years.

Categories
Technology

How Unilever makes use of AI to innovate your favourite merchandise

This article features an interview with Alberto Prado, Head of R&D Digital and Partnerships at Unilever. Prado will be speaking at the TNW conference taking place in Amsterdam on June 15th and 16th. If you want to catch the event (and say hello to our editorial team!), we have something special for our loyal readers. Use promo code READ-TNW-25 and get 25% off your TNW Conference Business Pass. See you in Amsterdam!

From microbiome-protecting skincare to a vegan, bee-friendly lipstick, Unilever is changing the way it innovates its portfolio products by harnessing the power of AI.

Alberto Prado, Head of Unilever’s R&D Digital and Partnerships, is leading this shift. According to Prado, the use of digital technologies enables the research and development department to innovate “better, faster and more effectively”. And this is where artificial intelligence comes into play.

“It starts with being able to understand the outside world in a much better, more predictive way,” Prado tells TNW. He adds that innovation has become more complex in our fast-moving and rapidly evolving world.

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It’s not just about responding to consumer trends and responding to consumer needs – which are changing faster than ever. It is also about advocating sustainability and responding to supply disruptions caused by the climate crisis and volatile geopolitical environment. Consider, for example, the shortage of sunflower oil after Russia’s war in Ukraine.

“The only way to deal with this complexity and the speed at which things are changing is to use artificial intelligence more extensively,” notes Prado. But how exactly does AI help?

First, artificial intelligence tools accelerate scientific discovery by taking on multiple tasks that previously required tedious work in a physical lab.

Thanks to access to vast data, machine learning and high-performance computing, Unilever’s research and development team has been able to make significant discoveries about human biology and the use of new materials that would otherwise have been unthinkable. For example, the company is on the verge of commercializing plant-based, sustainable palm oil alternatives for use in everyday cleaning and personal care products.

“The ability for us to use experimental data to create virtual models that can simulate parameters — which would normally have happened in the physical lab — speeds up much of our work, but also solves problems that may not have been solvable,” said Prado Remarks.

This method of product design, also known as “in silico”, can not only clarify the interaction of molecular compounds more quickly and effectively, but can also replace animal experiments.

The benefits of this technology have already been incorporated into everyday products such as Dove and Vaseline. Through the AI-powered analysis of 12 terabytes of data, Unilever has explored the microbiome (the over 100 trillion microorganisms that live in and on our bodies) and how to combine it with skin ceramides to create products that treat address skin quality and hydration issues.

Beyond discovery and design, AI is also being used to simulate the manufacturing process, Prado tells TNW. “We need to define the best ways to make a product,” he explains. “For example, this particular formula, which is energy efficient, reduces waste and carbon emissions, and is optimized for entry into the development process at our manufacturing facilities – which can have vastly different configurations and set-ups depending on the market.”

At the same time, artificial intelligence is helping to improve Unilever’s supply chain and response to bottlenecks. It can uncover alternative ingredients or simplify products by reducing the number of components without compromising their quality or effectiveness.

And by streamlining discovery, design, and manufacturing processes with AI-powered tools, the company is also improving operational efficiencies.

“Think of innovation as a triangle,” says Prado. It must be effective, sustainable and cost-effective. But optimizing a product across all three vectors is complex, he explains, which is even more difficult when you add the organizational complexity of a large company.

For Prado, this, coupled with all the changes happening around us, means that embracing AI at a scale that helps organizations stay competitive is critical to effective innovation.

Alberto Prado is one of many tech luminaries speaking at the TNW conference on June 15-16. Use promo code READ-TNW-25 and get 25% off your TNW Conference Business Pass.

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Science

“Now we have no motive to oppose nuclear power apart from prejudice and stupidity” – Dr. Patrick MooreWatts Up With That?

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In the second part of the BizNews interview with Dr. Patrick Moore, one of the co-founders of Greenpeace and one of the most prominent figures in the field of environmental protection, Moore makes a compelling case for nuclear energy. Moore recounts why he was silenced on the nuclear issue during his years at Greenpeace and provides excellent insight into both the misconceptions surrounding the risks of nuclear energy and why nuclear energy is in no way evil per se.

Moore argues that we should conserve the most valuable fuels we have, namely fossil fuels, by replacing them with nuclear power where possible. A brilliant perspective on the world’s current energy dilemma and the best way forward.

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