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Health

Amgen foregoes experimental weight reduction capsule and pushes forward with injection

The Amgen logo is displayed in front of the Amgen headquarters in Thousand Oaks, California on May 17, 2023.

Mario Tama | Getty Images

Amgen announced Thursday that it would stop development of its experimental weight-loss pill and instead advance development of its injectable drug and other anti-obesity products in development.

Amgen is one of several drugmakers vying to enter the red-hot weight-loss drug space dominated by Novo Nordisk And Eli Lilly, which some analysts say could be worth $100 billion by the end of the decade. But the company also has other ways to capture part of the market.

“Given the profile we’ve seen [the oral drug]We will not follow any further developments. Instead, we are making differentiated investments in MariTide and a number of preclinical products in the obesity space,” Amgen Chief Scientific Officer Jay Bradner said during a conference call Thursday.

Amgen is developing an injectable anti-obesity drug called MariTide, which is in an ongoing mid-stage trial in obese or overweight adults without diabetes. The company will release initial data from this study later this year, and Bradner said Amgen is “very pleased” with the results so far.

The company said it is working with regulators to plan a late-stage trial for the treatment. Amgen said Thursday that it is also planning a Phase 2 trial of the drug to treat diabetes.

Amgen shares rose more than 10% in extended trading Thursday following the comment on MariTide.

Amgen is also developing other weight management drugs.

The drugmaker's oral drug, called AMG-786, is the second weight-loss pill to be discontinued in the past year.

Pfizer scrapped a twice-daily version of its obesity pill danuglipron in December after patients in a mid-stage trial had difficulty tolerating the drug. The company is currently developing a once-daily version of this drug.

Investors are fully focused on Amgen's pipeline of experimental weight loss treatments. Amgen hopes to use a different approach to stand out from the crowded field of potential players.

The company's experimental injection helps people lose weight differently than existing injectable medications. Similar to Novo Nordisk's Wegovy and Eli Lilly's Zepbound, part of Amgen's treatment activates a gut hormone receptor called GLP-1 to regulate a person's appetite.

But while Zepbound activates a second hormone receptor called GIP, Amgen's drug blocks it. Wegovy does not target GIP, which like GLP-1 suppresses appetite, but may also improve the way the body breaks down sugar and fat.

According to some clinical trial data, Amgen's injectable treatment also appears to help patients reduce their weight after they stop taking it. The drugmaker is also testing that its drug should be taken once a month or even less often, which could provide more convenience than weekly medications on the market.

Patients given the highest dose of Amgen's MariTide – 420 milligrams – each month lost an average of 14.5% of their body weight in just 12 weeks, according to data from the phase 1 trial published in February in the journal Nature Metabolism were published.

Amgen's first quarter results

Also on Thursday, Amgen reported first-quarter sales and adjusted earnings that beat Wall Street expectations, thanks in part to products from recently acquired Horizon Therapeutics.

Here's what Amgen reported for the first quarter compared to Wall Street's expectations, based on an LSEG analyst survey:

  • Earnings per share: $3.96 versus expected $3.87
  • Revenue: $7.45 billion versus expected $7.44 billion

Amgen reported a net loss of $113 million, or 21 cents per share. In comparison, net income in the year-ago period was $2.84 billion, or $5.28 per share.

Excluding certain items, the company reported profit of $3.96 per share.

Amgen posted first-quarter revenue of $7.45 billion, up 22% from the same period last year.

This includes $914 million from Horizon Therapeutics products, including Tepezza for the treatment of thyroid eye disease.

Excluding Horizon Therapeutics' drugs, Amgen said its product sales rose 6% compared to the same period last year. Ten products achieved double-digit volume growth in the first quarter, including the cardiovascular drug Repatha, the severe asthma treatment Tezspire and Blincyto, a drug used to treat a certain blood cancer.

Amgen also adjusted its forecast for the full year slightly upwards from its low point on Thursday.

The company expects revenue of $32.5 billion to $33.8 billion in 2024. That compares with a previous forecast of $32.4 billion to $33.8 billion.

Amgen expects full-year adjusted earnings of $19 to $20.20 per share. This compares to previous guidance of $18.90 to $20.30 per share.

Analysts surveyed by LSEG expect full-year revenue of $32.95 billion and adjusted earnings of $19.48 per share.

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Science

Two stars in a binary system are very totally different. That's as a result of there was three

A beautiful southern hemisphere nebula with a binary star at its center appears to be breaking our standard models of stellar evolution. But new data from the European Southern Observatory (ESO) suggests that there may once have been three stars and that one was destroyed in a catastrophic collision.

About 3,800 light-years away, in the southern constellation Norma, is an object called the Dragon Egg Nebula (catalog number NGC 6164). At the heart of this nebula lies a double star called HD 148937. The pair is bright enough to be seen through binoculars and small telescopes, but far enough away that it only appears as a single star. Both stars that make up the pair are hot young blue giants, but the nebula surrounding them is quite unusual, which is why astronomers have been studying them for a long time.

Dr. Abigail Frost is an astronomer at the European Southern Observatory (ESO) in Chile and has been studying this system for nine years.

“When reading the background information, I was impressed by how special this system seemed,” she says. “A nebula surrounding two massive stars is a rarity, and we really felt like something cool must have happened in this system.” Looking at the data, the coolness only increased.”

Frost, like other astronomers before her, has noticed many strange features of the nebula. Most obviously, hot young stars like these are not typically found in nebulae because their intense radiation tends to disperse surrounding dust and gas quite efficiently. But more than that, the nebula itself has an unusual composition. If this nebula were the remnants of the gas cloud from which these stars formed, it would consist almost entirely of molecular hydrogen. Instead, it contains heavier elements such as oxygen, nitrogen and carbon. Old stars produce these elements by fusing helium and expel them in their final stages of life. But that cannot be the cause of this nebula because the stars are still young.

The stars themselves have their own secrets. The larger of the two has a strong magnetic field. Magnetic fields in stars like our Sun arise when the thick central shell of superheated plasma circulates. Much of the heat from the sun's core is transferred to the surface by convection: hot plasma near the core bubbles up to the surface, where it cools and then sinks back down. Plasma is electrically charged, and all the movement of charge creates a magnetic field, which scientists call the dynamo effect.

But truly massive stars like the one in HD 148937 are so large that heat can easily radiate out of the core. The distance from the core to the surface is so large that the temperature gradient is very gradual. There is no place inside the star where the temperature difference is high enough to trigger convection, so there is no flow of material that could create a magnetic field. Nevertheless, the star has a magnetic field, which leads to the next curiosity: magnetic stars experience a braking effect, causing their rotation to gradually slow down. So this star is spinning rapidly with its strong magnetic field, which it shouldn't have, which the magnetic field should have prevented.

Fighting the Dragons of Ara (NGC 6188 and 6164) © Michael Sidonio

But that's not all! The primary star is at least 1.5 million years younger than its companion. According to Dr. Frost said this shouldn't be possible: “After a detailed analysis, we were able to determine that the more massive star appears much younger than its companion, which makes no sense since they should have formed at the same time.”

If this system of stars and nebulae doesn't match what our models of stellar evolution lead us to expect, how do we explain all these anomalies?

“We believe this system originally had at least three stars; Two of them had to be close to each other at one point in the orbit, while another star was much further away,” explains Hugues Sana, professor at KU Leuven in Belgium and principal investigator of the observations. “The two inner stars merged violently, creating a magnetic star and ejecting some material, forming the nebula. The more distant star formed a new orbit with the newly merged, now magnetic star, creating the binary star system we see today at the center of the nebula.”

In other words, the system was originally a triple star, not a binary star. Triple systems tend to be quite unstable and usually eject one of their members. But sometimes the third star crashes dramatically into one of its companions instead. No one has ever seen a star collision, but computer models predict a number of things we see in NGC 6164. A star is essentially a vast and massive cloud of gas so large and heavy that its central regions are compressed to an enormous temperature and pressure. So when two stars collide, these gas masses merge chaotically. The different layers mix and flush nuclear ash (such as helium, nitrogen, carbon and oxygen) from the core to the surface. Much of the gas, including the heavier elements, is expelled, creating a huge new nebula. What's left will collapse inward again and reassemble into a new star that rotates correspondingly quickly. Finally, the turbulence of the collision creates and sustains a strong magnetic field.

This sequence of events has long been predicted by astronomers trying to model stellar mergers, and nine years of work by Dr. Frost could well provide proof that they are right. NGC 6164's metal-rich gas, the primary star's youthful appearance, its rapid spin, and its strong magnetic field all seem to confirm that it was indeed once a three-body system that ended in a collision of two stars.

Read the original press release at https://www.eso.org/public/news/eso2407/

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Technology

AI-powered deep drugs may rework healthcare within the NHS

Today's NHS faces severe time constraints and poses the risk of short consultations and concerns about the risk of misdiagnosis or delayed treatment. These challenges are further exacerbated by limited resources and overburdened staff, leading to long wait times for patients and generic treatment strategies.

Staff can work with a superficial view of patient data, relying on basic medical histories and current test results. This lack of comprehensive data impacts their ability to fully understand patients' needs and compromises the accuracy and individualization of diagnoses and treatments. Such an approach to health, characterized by these limitations and obligations, might aptly be called “superficial medicine.”

American cardiologist and scientist Eric Topol introduced the concept of “deep medicine” in his 2019 book “Deep Medicine: How Artificial Intelligence Can Make Healthcare Again Human Again.” He critiques the U.S.'s shallow model of medicine and offers insights from his clinical and personal experiences.

Deep medicine holds the potential to revolutionize medical diagnostics, treatment effectiveness and surgical considerations. Topol presents artificial intelligence (AI) as a transformative solution to these systemic, superficial problems. He outlines what he calls the Deep Medicine Framework as a comprehensive strategy for integrating AI into various aspects of healthcare.

The deep medicine framework is based on three core pillars: deep phenotyping, deep learning, and deep empathy. These pillars are all interconnected and the introduction of this framework could improve patient care, support healthcare workers and strengthen the entire NHS system.

In-depth phenotyping

Deep phenotyping is a comprehensive picture of an individual's health data across their entire life. A deep phenotype goes far beyond the limited data collected during a normal doctor's appointment or health episode. This includes things like a person's genetic code, all of a person's DNA, and information about the body's microbes or microbiome.

It includes the so-called “exposome”, the things in the environment that a person is exposed to over the course of their life, such as air pollution. It includes markers that reveal details about the metabolic processes in a person's body and the proteins their body expresses, as well as other biological measures and metrics. It includes a person's electronic health records, including their medical history, diagnoses, treatments and laboratory results.

Deep learning

The philosophy underlying deep phenotyping is to combine this diverse data to enable more accurate and rapid diagnoses, more precise and effective treatments, and advance predictive and preventive medical strategies. However, the sheer volume and complexity of the data collected presents significant analysis challenges. This is where deep learning – an area of ​​AI designed to simulate the decision-making power of the human brain – is so valuable. Deep learning uses an algorithm called a neural network, which uses small mathematical computers called “neurons” that are connected to each other to share information and learn.

AI could potentially improve the use of diagnostic tools. Elif Bayraktar / ShutterstockCT scans of the brain.

Advances in neural network algorithms, technology, and availability of digital data have enabled neural networks to demonstrate impressive performance. For example, they have enabled the rapid and accurate analysis of medical images such as X-rays and MRI images. You can generate reports and predict disease progression and patient outcomes.

AI is proving valuable in drug discovery and identifying chemical markers in the body, such as those that can signal the presence of cancer. They can control instruments used in robotic surgery. Additionally, AI technology like the one behind ChatGPT can process medical literature and patient records to help make complex diagnoses. You can automate writing tasks like note-taking and data entry.

Deep empathy

Integrating AI systems could help streamline operational tasks in healthcare services such as the NHS. This includes bed management and hospital processes. However, the development of AI technologies should not be haphazard, but must be focused on real clinical needs and designed to promote better relationships between patients and staff. This is the pillar of deep medicine known as deep empathy.

Healthcare has increasingly become a discipline in which the human touch, once the cornerstone, is overshadowed by a relentless pursuit of efficiency. Health workers are faced with an increased burden of administrative tasks. This can result in reducing the time they devote to each individual patient and negating the essence and potential benefits of compassionate care.

Staff need the sensitivity and time to respond to the emotional and psychological needs of patients and their families. This promotes a supportive and compassionate care environment and strengthens the human connection at the heart of healthcare.

AI solutions can be designed to reduce the administrative burden on staff and open up more opportunities for meaningful patient interaction. By removing these barriers, we can focus more on direct patient care, helping to improve the quality of services provided and hopefully patient satisfaction.

There is also a transformative opportunity to reimagine efficiency and focus on relationships between patients and staff. It envisions a future in which healthcare professionals have both technical skills and emotional intelligence, and are able to meet the psychological needs of patients with genuine understanding and compassion.The conversationThe conversation

Will Jones, Research Director and Lecturer in Data Science, Artificial Intelligence and Modeling (DAIM), University of Hull

This article is republished from The Conversation under a Creative Commons license. Read the original article.

Categories
Entertainment

Khloe and Kim Kardashian hilariously revisit the bag-swinging scene after they had been 16 years previous

The Kardashians are holding on to their past struggles.

Finally, Khloe Kardashian And Kim Kardashian I couldn't help but remember the infamous bag-swinging debacle of 2008.

The Good American founder shared the iconic scene from “Keeping Up With the Kardashians” and wrote on X, formerly known as Twitter, on May 1, “I wish she would try this now.”

But Kim wasn't about to let Khloe's tweet go unanswered. “Baby, be careful what you wish for,” the 43-year-old replied an hour later. “My bag is much bigger today than it was 16 years ago.”

But Khloe appeared undaunted by her older sister's warning and hinted at the possibility of recovery.

“Damn, I love it when you talk to me like that,” the 39-year-old replied. “Made me a little excited. I love it when you attack me. Squeak, but remember, Khlomoney is still in this body.”

“I just had to put her to sleep for a few years, but she can and will be woken up,” Khloe continued. “See you soon with your big ass.”

Categories
Health

A 3rd of People could possibly be affected by the Change Healthcare cyberattack

Omar Marques | Light rocket | Getty Images

UnitedHealth Group CEO Andrew Witty told lawmakers Wednesday that an estimated one-third of Americans' data may have been compromised in the cyberattack on its Change Healthcare subsidiary and that the company paid a $22 million ransom to hackers.

Witty testified before the Subcommittee on Oversight and Investigations, which is under the House Energy and Commerce Committee. He said the investigation into the breach was still ongoing, so the exact number of people affected was not yet known. The figure of one third is a rough estimate.

UnitedHealth previously said the cyberattack likely affected a “significant portion of the people of America,” according to an April press release. The company confirmed that the breach compromised files containing protected health information and personal data.

It will likely be months before UnitedHealth is able to notify individuals given the “complexity of data review,” the release said. The company offers free access to identity theft protection and credit monitoring to people concerned about their data.

Witty also testified before the Senate Finance Committee on Wednesday, confirming for the first time that the company had paid a $22 million ransom to the hackers who hacked Change Healthcare. At the hearing before House Democrats later that afternoon, Witty said the payment was made in Bitcoin.

UnitedHealth announced that a cyber threat breached part of Change Healthcare's information technology network in late February. The company shut down the affected systems when the threat was identified, and the disruption has had widespread impact across the U.S. healthcare sector.

Witty told the subcommittee in his written testimony that the cyberattackers used “compromised credentials” to infiltrate Change Healthcare's systems on Feb. 12 and nine days later deployed ransomware that encrypted the network.

The portal that the attackers originally accessed was not protected by multifactor authentication (MFA), which requires users to verify their identity in at least two different ways.

Witty told both committees Wednesday that UnitedHealth now has MFA in all external systems.

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Sport

Walker Buehler is predicted to return from elbow surgical procedure on Monday

PHOENIX – Los Angeles Dodgers pitcher Walker Buehler is expected to return to the major leagues on Monday after missing nearly two full years following Tommy John surgery in 2022.

“The plan is for Walker to start Monday,” Dodgers manager Dave Roberts said after Wednesday's 8-0 win over the Arizona Diamondbacks. “We’re excited about that. Everything checked. It’s going to be okay.”

The Dodgers play at home against the Miami Marlins on Monday.

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Buehler, a two-time All-Star, has not played in a major league game since June 10, 2022 against the San Francisco Giants. He is trying to become one of the few pitchers recovering from a second Tommy John surgery, which typically keeps pitchers off the mound for 12 to 18 months.

Buehler could make a talented Dodgers team even more formidable. He was one of the best pitchers in baseball during the 2021 season, finishing the season with a 16-4 record and a 2.47 ERA over 207⅔ innings.

Buehler had an extended rehab stint in Triple-A last month as he prepared for his return, going 0-2 with a 4.15 ERA and 21 strikeouts over 21⅔ innings.

The Associated Press contributed to this report.

Categories
Science

Vogtle Unit Four energy plant begins business operation – are you happy with it?

The US Energy and Information Administration reports:

MAY 1, 2024

The Vogtle Unit 4 plant begins commercial operations

Data Source: US Energy Information Administration, Annual Electric Generator Report

Georgia Power announced this week that the 1,114 megawatt (MW) Unit 4 nuclear reactor at the Vogtle Power Plant near Waynesboro, Georgia, began commercial operations after being connected to the grid in March 2024. Annual expansion project at the Vogtle plant. There are currently no nuclear reactors under construction in the United States.

Vogtle Unit 3 began commercial operation in July 2023. The power plant's first two reactors, with a combined nominal output of 2,430 MW, were put into operation in 1987 and 1989. It surpasses the 4,210 MW Palo Verde Power Plant in Arizona, making Vogtle's four units the largest nuclear power plant in the United States.

Construction of the two new reactor sites began in 2009. The project was originally expected to cost $14 billion and begin commercial operations in 2016 (Vogtle 3) and 2017 (Vogtle 4), but there were significant construction delays and cost overruns. Georgia Power now estimates the total cost of the project at more than $30 billion.

The date of commercial operation occurs when the builders hand over a reactor to the power plant owner or operator, thereby declaring that the reactor is officially in commercial operation.

With a total installed capacity of approximately 97 GW, the United States is home to the largest commercial nuclear fleet of any country. The fleet of operating nuclear reactors accounted for nearly 19% of domestic electricity generation in 2023. This makes nuclear power the second largest source of electricity generation in the United States after natural gas, which accounted for 43% of electricity generation in the United States last year.

Electricity generation from nuclear reactors produces no CO2 emissions and can provide baseload power that would otherwise largely come from coal and natural gas power plants. Although a number of nuclear reactors have been decommissioned in recent years, interest in nuclear energy as a source of energy to reduce the carbon footprint of the U.S. power sector has recently increased.

Both Vogtle Units 3 and 4 use a newer reactor design, the Westinghouse AP1000. This reactor has a smaller footprint and a simpler design than previous generation reactor technologies. It also has passive safety systems designed to shut down the reactor without operator intervention or an external power source.

Vogtle Units 3 and 4 are the first and only U.S. deployments of the Generation III+ AP1000 reactor. Two more Westinghouse AP1000 reactors were planned for a nuclear power plant in South Carolina, but utilities there halted construction in 2017.

For more information about U.S. nuclear capacity and generation, visit our U.S. Nuclear Generation and Generation Capacity webpage.

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Technology

Alexandra Balkova on the state of VC; AI computing for everybody

Welcome to the new episode of the TNW Podcast – the show where we discuss the latest developments in the European tech ecosystem and conduct interviews with some of the most interesting people in the industry.

In today's episode, Linnea and Andrii talk about it the availability of AI computers, the impending withdrawal of Getir from Europe, some money for German game developers and a few things in between.

The guest of the show is Alexandra Balkova, general partner and portfolio head at Startup Wise Guys. In the interview recorded at TechChill in Riga, Alexandra spoke about the current state of the VC industry, Ukrainian startups, defense technology and much more.

The <3 of EU technology

The latest rumors from the EU tech scene, a story from our wise founder Boris and questionable AI art. It's free in your inbox every week. Join Now!

Here are the stories and things mentioned in the episode:

Music and sound engineering for this podcast comes from Sound Pulse.

If you have any questions, suggestions or opinions, please feel free to send us an email [email protected].

Categories
Entertainment

Rick Ross & Webster's Dictionary React to Kendrick's “Euphoria”

Kendrick Lamar After releasing a dissident track, he set social media on fire drake. Hours after “Euphoria” went live on YouTube, reactions are still pouring in. We've already told you all this Metro Boomin weighed in. So, Rick Ross, Lil Yachty, Gun, Gillie Da King and myself Merriam-Webster Dictionary contributed to the excitement!

RELATED: Let's get started! Everything Kendrick Lamar Said About Drake In New Diss 'Euphoria'

Here's what Rick Ross and Lil Yachty posted

On Instagram, Rick Ross appeared to troll Drake about K Dot's bars. As previously reported, Kendrick Lamar explained the Canadian rapper's fathering habits, his writing game, his sexuality, his black identity and more in just over six minutes.

Rozay opened his trolling by repeatedly calling Aubrey a “white boy.” He then gave his version of “some advice.”

“Stop, don’t answer. “Don’t react,” Rick said, specifically referencing Kendrick’s “Euphoria” intro. “Don’t do it, don’t write an eight-minute verse.”

Check out what Rick Ross said below and swipe for his additional post.

In his “advice,” Ross apparently named Lil Yachty, suggesting he is a writer for Drizzy. Meanwhile, Lil Boat – as he's known – appeared to be siding with X on the 6 God's side.

He liked a post that questioned Kendrick's paternity in the context of his past infidelity. According to HipHopDX, Lamar stated in his album “Mr. Morality and the big steppers.'

The post Yachty liked read: “So who raised your child while you cheated on your wife with white women?”

Lil Yatchy likes tweets about Kendrick pic.twitter.com/j3y9aGmGEi

– Keeping Culture Alive (@Q4quise) April 30, 2024

Rozay's opinion on “Euphoria” wasn't too much of a surprise. The “Diced Pineapples” rapper has participated in the rap feud several times in the last month, including releasing his own dissident track “Champagne Moments” against Drizzy.

Drake later clapped back at Rick Ross in his first of two diss tracks against Kendrick, titled “Push Ups.” Drizzy shared his second diss, “Taylor Made Freestyle,” on social media but removed it last week. The freestyle featured AI vocals from Tupac Shakur and Snoop Dogg. The removal apparently came after Pac's estate demanded it under threat of lawsuit.

RELATED: Drake Officially Removes “Taylor Made Freestyle” Featuring Tupac's AI-Generated Vocals

Who else took part?

Besides Metro, Rick and Yachty, a few others have joined the group chat! After Kendrick somehow got them involved in the feud, Gunna and Merriam-Webster's Dictionary got involved.

Starting with Gunna. There's a lyric in “Euphoria” where Lamar plays on rumors that the rapper betrayed Young Thug. Note that Gunna and his lawyer have denied these claims. Still, Kendrick rapped: “I know a thing or two about n****s that make Gunna Wunna look like a saint.” On X, Gunna seemingly responded to the line, writing: “Mannn WHATAM?!”

Mannnn WASSAM?!!

— WUNNA (@1GunnaGunna) April 30, 2024

Meanwhile, Merriam-Webster's Dictionary seemed to be there for Kendrick to include her. For context, the rapper used a screenshot of his definition of “Euphoria” as the cover for the dissident track.

Fans have speculated that the song's name is also Lamar, referring to Drizzy's executive production of the HBO show of the same name.

“Dear @MTV. “We humbly nominate 'Euphoria' by @kendricklamar for a Video Music Award for 'Best Video of All Time,'” the dictionary's X account posted.

Dear @MTV

We humbly nominate “euphoria” by @kendricklamar for a Video Music Award for “Best Video of All Time.” pic.twitter.com/tVLagcAYtK

— Merriam-Webster (@MerriamWebster) April 30, 2024

Now host of “Million Dollars Worth Of Game”. Gillie Da King is also trending online after he said Kendrick didn't outdo Drake with “Euphoria.” He called the track “Corn on the Cob.”

Check out his comments below.

As for J. Cole, he remained silent while social media trolled him for retiring from the business early.

RELATED: J. Cole Trends as People Discuss His Early Exit from Kendrick Lamar & Drake's Beef

Categories
Health

Docs faucet private financial savings for prices

Omar Marques | Lightrocket | Getty Images

On a Sunday in early March, Dr. Angeli Maun Akey noticed something peculiar while making payroll for her private practice in Gainesville, Florida: She was missing $19,000.

Akey owns and operates a primary care practice that serves around 3,500 patients in the area, many of whom suffer from chronic diseases. She opened in 2000 and manages a staff of nearly 20 people. Over the last two decades, Akey said, her practice and patients have been like an extension of her family. 

“There’s no better life,” she told CNBC in an interview.

When Akey first noticed the discrepancy in her cash flow, she thought the funds had been embezzled, something she said she’s experienced three times since graduating from medical school. But after searching online, Akey realized she had a much bigger problem. 

The health-care technology company Change Healthcare had been breached in a cyberattack. 

Change Healthcare offers payment and revenue cycle management tools, and other solutions such as electronic prescription software. On Feb. 21, UnitedHealth Group, which owns Change Healthcare, discovered that hackers compromised part of the unit’s information technology systems.

UnitedHealth said in a filing with the U.S. Securities and Exchange Commission that it isolated and disconnected the impacted systems “immediately upon detection” of the threat. In its first-quarter earnings report in April, UnitedHealth said the total cost of the cyberattack could be as much as $1.6 billion for the full year. The company’s stock is down nearly 8% year to date.

The disruption has caused severe fallout across the U.S. health-care system, as many doctors such as Akey were temporarily left without a way to get paid for their services. 

Akey said the outages from the cyberattack reduced her practice’s cash flow by more than 80% for six weeks. As of early April, she said, she had amassed more than $130,000 worth of insurance claims that she had not been able to get reimbursed for. 

Making payroll quickly became a major concern, and Akey said she stopped paying her own salary to help support her staff. Her bank offered her a loan to keep her practice afloat, but it came with an 11% interest rate. Akey said she felt it was too high. 

She turned to her patients for help, asking for voluntary $45 advances that would be repaid.

“I’ve had patients for like a quarter century, so a lot of them have been like, ‘No, no, I need to give you more.’ So there’s $100 checks, $200 checks, $500 checks, $2,000 checks,” Akey said. “They have had 0% responsibility for this situation, and they’re fronting the money to keep us going.”

Earlier this month, Akey liquidated her retirement investments as an extra precaution. She said she was feeling frustrated and vulnerable, especially as rumors were swirling about the possibility that a second breach had occurred. UnitedHealth told CNBC earlier this month that there is “no evidence of any new cyber incident at Change Healthcare.”

“I just decided I can’t do this again,” Akey said.

UnitedHealth said in an April 22 press release that it has been working to bring systems back online, and that Change Healthcare has made “continued strong progress.” Medical claims across the U.S. are flowing at “near-normal levels,” and payment processing by the company is at more than 85% of pre-incident levels, the release said. 

“We know this attack has caused concern and been disruptive for consumers and providers and we are committed to doing everything possible to help and provide support to anyone who may need it,” UnitedHealth CEO Andrew Witty said in the release.  

Akey said payments have begun flowing back into her practice, though levels are still down between 30% and 40% from where they normally are. 

She said the restarted payments have lifted a “humongous weight” off her back, but the road ahead will be difficult. Even so, she thinks her practice will be able to pull through, and she will be able to restore her retirement investments some time in the next few months.   

“We love our patients, and that’s why I’m fighting so hard,” Akey said.

A quiet health-care giant

UnitedHealth Group Inc. headquarters stands in Minnetonka, Minnesota, U.S.

Mike Bradley | Bloomberg | Getty Images

Change Healthcare is not a household name for most Americans and even many health-care workers. Much of the company’s technology helps facilitate billing, payments, benefits evaluations and information exchanges behind the scenes.

Change Healthcare is the largest U.S. clearinghouse for medical insurance claims. A clearinghouse is like a middleman for the transactions between providers — such as doctors, hospitals and pharmacies — and payers — such as insurance companies, Medicare and Medicaid. 

A clearinghouse helps deliver the right bills to the correct payers. It’s just one of the ways Change Healthcare touches cash flow within the health-care sector. 

The company operates on an enormous scale. Change Healthcare processes more than 15 billion billing transactions annually, and 1 in 3 patient records passes through its systems, according to its website. That means Change Healthcare’s reach extends beyond UnitedHealth’s already sizable customer base. 

Money stopped flowing when the company’s systems were disrupted due to the cyberattack, and a major source of revenue for thousands of providers across the U.S. screeched to a halt. 

It’s caused a lot of sleepless nights for Dr. Barbara McAneny.

McAneny founded a multidisciplinary private practice with another physician in New Mexico in 1987. The practice now supports a staff of 280 people and offers a range of services, including cancer care. She also served as the president of the American Medical Association, or AMA, a research and advocacy group that represents physicians, from 2018 to 2020.

McAneny said she had tried to prepare for the possibility of a cyberattack, so the practice had contingency plans and funds stashed away to cover payroll and other expenses. However, she said she had “no idea” how she could have prepared for a breach of this magnitude. The practice felt the effects immediately. 

“The cash flow for the practice went to zero that day,” McAneny told CNBC in an interview.   

She said the practice’s partner physicians stopped taking a salary, and they told employees that they couldn’t approve overtime pay. Expenses became a real concern, but her “major fear” was whether the practice could continue purchasing chemotherapy for the cancer patients who rely on it for treatment. 

McAneny’s practice buys chemotherapy from group purchasing organizations, or GPOs. It continued to place orders in the weeks following the cyberattack. But while Change Healthcare was down, there was no money to pay for the treatment. By April 10, the practice owed more than $6 million for chemotherapy alone. 

“If the flow of chemotherapy stops from the GPOs that supply our chemotherapy, people will die,” she said.

McAneny said she lived in fear that supply would dry up. The thought had been waking her up in a cold sweat at night.

By mid-April, money started trickling back into McAneny’s practice, and it began chipping away at its $15 million claims backlog. She said claims started moving substantially in the last couple of weeks but that the practice’s cash flow is still only around 70% to 80% of what it normally is. 

McAneny said the practice is “significantly in debt,” which will take several months to resolve. She said she is very worried about late fees. Even so, signs of progress have come as a relief. 

“I might actually sleep through the night,” she said.

Funding assistance

Early in March, UnitedHealth launched a temporary funding assistance program to help support providers that have experienced cash flow disruptions due to the cyberattack. There are no fees, interest or other costs on top of the payments, and providers have 45 days to repay the funds once standard payment operations resume. 

Eligible providers will get funds weekly, and the amount they get is based on the difference between their historical weekly claims or payment volume before the breach vs. after, according to the website. 

UnitedHealth said it only has “partial visibility” into most providers’ histories and may be “unable to see the full impact of their needs.” Providers could see a gap in their funding amounts and, if they do, they are encouraged to submit a temporary assistance inquiry form through the website for additional support.

But for doctors such as Akey, the program has been a source of frustration. As of Thursday, Akey said she had been approved for around $31,000 worth of funding. She called the total “woefully inadequate” and said it amounts to less than two weeks of help. 

Akey said Tuesday she was not aware she could have applied for additional funding support, despite reading the website and making repeated attempts to contact UnitedHealth.

Sarah Carlson, who owns and operates a marriage and family therapy practice in Boulder, Colorado, had a similar experience with the funding program. 

Carlson’s practice amassed a $75,000 claims backlog by early April because of the cyberattack, she told CNBC. She said she had been fronting her employees her own money to make payroll, and after a couple of sleepless nights, she decided to temporarily stop accepting some new clients. 

Carlson applied for UnitedHealth’s funding assistance program, but she said the payments up to that point had been negligible. One week, she said, she received just $10. 

“It was comical. Literally, I think I laughed,” Carlson said in an interview.

UnitedHealth told CNBC that Carlson had not applied for additional funding. Carlson said she thought she had done so by filling out a new form, separate from her initial application, with information about the total amount of claims she was owed.

McAneny said that as of mid-April she had around $28,000 from UnitedHealth sitting in an account, which is only enough to cover the cost of about two drugs. 

“It was useless to me,” she said. 

McAneny has since applied for and received additional funding. She said she is using that money to help pay off the chemotherapy bills. 

UnitedHealth told CNBC in a statement Tuesday: “We have issued more than $6.5 billion in assistance to providers and we continue to encourage any provider to reach out and our goals has always been to help get the word out to as many providers as possible here.”

A controversial merger

Sheldon Cooper | Sopa Images | Lightrocket | Getty Images

UnitedHealth’s ownership of Change Healthcare has raised eyebrows from the outset. 

The company has two major business units: Optum and UnitedHealthcare. Optum offers a range of pharmacy services and consulting services and provides medical care for around 103 million consumers, while UnitedHealthcare provides insurance coverage and benefit services to more than 55 million people globally, according to the company’s website.

UnitedHealth’s reach is already substantial, so when it announced that Optum and Change Healthcare had agreed to combine in January 2021, it alarmed organizations such as the AMA.

The AMA sent a letter to the U.S. Department of Justice in April 2021 arguing the $13 billion deal would have “significant anticompetitive effects” on doctors, hospitals and insurers. The group urged the DOJ to look at the merger.  

The DOJ sued to block the deal the following year, arguing that UnitedHealth’s proposed acquisition would harm competition in the sector. The suit was unsuccessful, and Optum announced that it completed its combination with Change Healthcare in October 2022. 

In UnitedHealth’s quarterly call with investors in April, CEO Andrew Witty said the company’s ownership of Change Healthcare is “important for the country.” He said the cyberattack likely would have happened either way, but if UnitedHealth did not own the company, Change Healthcare would not have had the resources or support necessary to bring its systems back online. 

“We’re going to bring it back much stronger than it was before,” Witty said.

The AMA has also been outspoken about the cybersecurity breach. In a letter to the U.S. Department of Health and Human Services in March, for instance, the organization said it is concerned about the “undue financial hardships facing physician practices” if the cyberattack was not resolved quickly. The AMA said it is particularly concerned about small, rural and less-resourced practices, according to the letter.

In late February, the DOJ launched an antitrust investigation into UnitedHealth, according to a report from The Wall Street Journal. The investigation is exploring issues such as its doctor group acquisitions and the relationships between Optum and UnitedHealthcare, the report said. UnitedHealth declined to comment on the matter during its investor call.

The DOJ declined to comment.

‘It’s a mess’

UnitedHealth Group signage is displayed on a monitor on the floor of the New York Stock Exchange.

Michael Nagle | Bloomberg | Getty Images

There’s no quick fix for providers affected by the breach. Switching to another clearinghouse can take weeks to months, and submitting claims manually creates mountains of extra work for practices that are often already overwhelmed with administrative and clerical tasks. Some payers don’t even accept paper claims anymore. 

“It’s not been fun,” said Dr. Tyler Kisling, who with his wife owns and operates an orthodontic and pediatric dentistry practice in California. 

Kisling said the pair have taken out around $20,000 from their personal savings to help keep things afloat since the cyberattack. The breach has created a lot of stress, Kisling said, and he’s resorted to printing out paper calendars to help keep track of bills and due dates. 

The company that operates their practice’s patient management software has worked to get set up with another clearinghouse, but as of April 19, Kisling said it was still not running. The workaround has been to fill out all of the practice’s claims by hand, put them in envelopes and mail them off to insurers. Kisling said the task has been like a new full-time job.

Payments are just starting to trickle in, and Kisling said he thinks it is largely because the practice took steps to mail in claims. There’s still a long road ahead. 

“I just don’t know how much longer it’s going to take to catch up with all the backlog,” he said.

McAneny said her practice switched to another clearinghouse during the breach but that they all have different peculiarities that can be difficult to work out. She said she had 5,000 rejected claims in a week, which meant the practice had to go through each one to determine what needed to be fixed.

“The comma goes here, or the date of birth goes over there or whatever they want,” she said.

McAneny said it’s been a “huge amount” of work. Her billing staff has been working a lot of overtime. 

Dr. Purvi Parikh, an allergist and immunologist with a private practice in New York City, said her practice reconnected with Change Healthcare after seven weeks of outages. It was a welcome sign of progress, especially because Parikh and the other doctors who own the practice had been covering payroll and expenses out of pocket. 

But figuring out how to file seven weeks’ worth of claims has been draining for Parikh’s staff and the practice’s already diminished resources. 

“It’s such a waste of everyone’s time,” she told CNBC in an interview. “We spend hours and hours, or even days, trying to figure out where to get money from, how to now resubmit through a new clearinghouse, and then resubmit again back through Change Healthcare. It’s a mess.”

UnitedHealth told CNBC that it has been working to communicate with providers, government officials, health systems, trade associations and customers about the breach from the outset. 

The company said it has provided updates through Change Healthcare’s product website, and it launched a separate website about its response to the cyberattack that has received millions of page views. UnitedHealth said it also launched a multimillion-dollar social media and digital campaign to raise awareness about its funding assistance program.

Additionally, UnitedHealth has hosted calls with security executives, providers, customers and advocacy groups that have been attended by thousands, the company said.

Nevertheless, some providers said getting information about the breach has been challenging. 

As of mid-April, Parikh hadn’t been able to get anyone from Change Healthcare on the phone. She said she was getting all her information directly from her billing company. There has been “zero communication” from UnitedHealth, Optum or Change Healthcare, she said. 

Kisling said his office received no formal notification about the breach, and that he heard about it in the media. His office manager had to call one of the practice’s software vendors to ask what was happening. 

“We all just kind of had to figure it out on our own,” he said. 

Many doctors have been leaning on one another to share information and tips about how to handle the breach. On platforms such as Doximity, which is a medical website used by more than 80% of U.S. physicians, doctors have been “exchanging notes” about how they’ve managed, said Dr. Amit Phull, the chief physician experience officer at Doximity.

Phull said there were a lot of people posting about the breach who didn’t know what to do. Initial feelings of “bewilderment” quickly progressed to anxiety, fear and anger, he said. 

Providers are left with questions

Igor Golovniov | Sopa Images | Lightrocket | Getty Images

UnitedHealth said in late February that the ransomware group Blackcat was behind the cyberattack. Blackcat, which also goes by the names Noberus and ALPHV, steals sensitive data from institutions and threatens to publish it unless a ransom is paid, according to a December release from the DOJ.

The company said its investigation into the breach is ongoing, and it could be months before the company can identify and notify affected individuals. UnitedHealth is working with law enforcement officials, cybersecurity experts and regulators to assess the breach, according to its website.

On April 22, UnitedHealth told CNBC that it paid a ransom in an effort to protect patient data. It did not specify the amount. The company also confirmed that files containing protected health information and personally identifiable information were compromised. 

Providers have been left with questions about what happens next.

“How are they going to keep this from happening in the future?” said John Bieda Jr., who owns and operates a marriage and family therapy practice in California. 

Bieda said he founded his practice with funds he inherited from his parents after they died. He told CNBC he is very proud of what he has built, and he wishes his father were around to see it. But he said his experience with the Change Healthcare breach has left him feeling lost, and at times like he does not want to own his own company anymore. 

As of Friday, Bieda said he had around $109,000 of claims outstanding. He has taken $241,000 out of his retirement accounts to keep the practice afloat.

“I have been on the verge of tears significantly,” Bieda said. “It just is devastating.” 

McAneny said many providers have opened lines of credit due to the breach, which raises questions about how UnitedHealth will address problems around interest, late fees and damage to credit ratings. 

“They’ve caused a lot of harm to a lot of practices,” McAneny said. “How are they going to make up for the losses that we have had?”

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