Categories
Science

The close by star clusters come from solely three places

Many people interested in astronomy know the Hyades and the Pleiades. They are star clusters in the constellation Taurus. They are two of a handful of star clusters that are visible to the naked eye in dark skies.

It turns out that these clusters, as well as more than 150 other clusters nearby, all originate from just three massive star-forming regions.

Open clusters such as the Hyades and Pleiades contain hundreds of stars loosely bound together by mutual gravity. They have fewer stars than globular clusters and are not as densely packed. They are also not spherical like globular clusters, but follow the galactic plane. They are usually found in the spiral arms of the Milky Way rather than in the halo where globular clusters are located.

Open star clusters eventually lose their gravitational bond with each other and are called stellar associations. They still move together through space and are then called a moving group. Their motion allows astronomers to understand their origins.

In a new research article in Nature, a team of researchers has traced the origins of 155 young star clusters within about 3,500 light years of the Sun. The article is titled “Most nearby young star clusters formed in three massive complexes.” The authors come from institutes in Austria, Germany and the USA.

“Young star clusters are ideal for studying the history and structure of the Milky Way. By studying their movements in the past and thus their origin, we also gain important insights into the formation and evolution of our galaxy,” says João Alves of the University of Vienna, co-author of the study.

The researchers used Gaia data and spectroscopic observations of star clusters to trace their history back 60 million years. They discovered three families of star clusters, each of which is associated with one of three star-forming regions. “This suggests that the young star clusters originate from only three very active and massive star-forming regions,” says Alves.

The researchers started with a sample of 272 star clusters. They found that between 30 and 50 million years ago, almost 60 percent of their orbits converged in three locations. This showed that “a large proportion of star clusters in the solar neighborhood have common origins.”

The three cluster families are named after their best-known members: Collinder 135 (Cr135), Messier 6 (M6), and Alpha Persei (?Per). The clusters contain 39, 34, and 82 star clusters, respectively. Together, they contain 57% of the 272 star clusters in the sample and 59% of the 48,514 stars in the sample.

This research illustration shows the positions of the clusters' stars across the sky, as well as some optical images of some of their members. Alpha Persei's members are spread out further across the sky because they are closest to the Sun. (Interactive version here.) Image credit: Swiggum et al. 2024.

“These findings provide a clearer understanding of how young star clusters in our galactic neighborhood are connected to each other, similar to family members or 'bloodlines,'” says lead author Cameron Swiggum, a doctoral student at the University of Vienna. “By studying the three-dimensional motions and past positions of these star clusters, we can identify their common origin and locate the regions in our galaxy where the first stars in these respective star clusters formed up to 40 million years ago.”

The team's research uncovered more than just the history of the star clusters. They also found that over 200 supernova explosions must have occurred in the three star-forming regions to eject all of these clusters. However, supernova explosions are extraordinarily powerful, and 200 of them release enough energy to shape their surroundings on a large scale.

The authors say these explosions created a gigantic bubble in the ISM. “This could explain the formation of a superbubble, a giant bubble of gas and dust 3,000 light-years in diameter around the Cr135 family,” Swiggum said in a press release.

Our solar system is also located in one of these bubbles, the Local Bubble. Inside the bubble, the gas is thinner and hotter than outside. “The Local Bubble is also probably linked to the history of one of the three star cluster families,” adds Swiggum. “And it has probably left traces on Earth, as measurements of iron isotopes (60Fe) in the Earth's crust suggest.”

This image from the research shows three star cluster families and other local features on a dust map. The dust is shown in gray and two prominent dust features, the Vela Molecular Ridge and the Radcliffe Wave, are labeled. The Sun is the yellow dot and the local bubble is shown in blue. (Interactive version here.) Image credit: Swiggum et al. 2024.

It's a truism that finding connections between things creates meaning. The stars in the sky aren't just “there.” There's a long story to tell when you unravel what we perceive as static. This research is another example of the powerful Gaia spacecraft's ability to find relationships between stars and weave an evidence-based story of their history. And we're somewhere in the middle of it.

“We can essentially turn the sky into a time machine that allows us to trace the history of our home galaxy,” says João Alves. “By deciphering the genealogy of star clusters, we can also learn more about our own galactic lineage.”

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Categories
Technology

German enterprise capitalist unveils record-breaking €214 million fund for deep-tech firms

We know from reports from the beginning of the year that VC investments are increasing again for European startups. And the wave of optimism seems to be continuing – at least for the continent’s deep-tech sector.

Munich-based Vsquared Ventures today announced the closing of a new €214 million fund for early-stage investments in deep-tech startups, reportedly the largest early-stage fund for this sector in Europe.

The venture capital firm will distribute its second fund to 25 deep-tech companies across Europe, distributing between €500,000 and €5 million, and reserving some funds for follow-on investments.

The fund targets six broad growth themes: next-generation AI and software, energy transition, new computing and sensor technologies, new space, robotics and manufacturing, and techbio (biotechnology that uses data-driven technologies to transform drug discovery and patient care).

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“There is a huge opportunity right now for Europe to become a global deep tech power – which is also imperative to secure the continent's sovereignty and future-proof it,” the VC said in a statement. “Companies that solve real problems with real technology on a global scale will succeed, and those are the companies we partner with.”

In-depth VC expertise in the technology sector

The LPs of the new fund include Novo Holdings (the investment company of the Novo Nordisk Foundation), the NATO Innovation Fund (NIF) and the European Investment Fund (EIF).

Marjut Falkstedt, Managing Director of the EIF (with whom you can hear: an interview in the TNW podcast from the beginning of this year) has high hopes for the fund.

“Europe has leading research institutions and an incredible talent pool, and turning brilliant ideas into viable business propositions is high on our priority list. That’s why we are excited to support Vsquared, the deep tech experts, to continue channeling funding into the European deep tech ecosystem,” she said.

Vsquared's investment portfolio includes Finnish quantum computing hardware startup IQM, which just signed a deal with AWS to deploy the cloud giant's first quantum processor in the EU.

Also on the list are rocket launch and space technology startup Isar Aerospace from Germany, its compatriots, graphene-based superchip connector Black Semiconductor, cognitive robot assistant startup Neura Robotics and droplet microfluidics technology startup Atrandi Biosciences from Lithuania – to name a few.

One of the themes of this year's TNW Conference is “Venture: Show Me The Money.” If you want to dig deeper into what it takes to fund your startup, discover the next company to support, or just want to experience the event (and say hi to our editorial team), we have something special for our loyal readers. Use code TNWXMEDIA at checkout to get 30% off your Business ID, Investor Passport or starter packages (Bootstrap and Enlarge).

Categories
Health

GLP-1 weight reduction increase drives protein gross sales, says Vitamin Shoppe

The weight loss boom is prompting consumers to spend more on protein supplements, according to new data from The Vitamin Shoppe's 2024 Health & Wellness Trend Report.

The report is an annual study of 2,000 Americans that provides insight into key consumer trends in the dietary supplement industry. More Americans are taking weight-loss drugs like GLP-1 drugs while also looking for ways to replace key nutrients like protein because the drugs have been linked to muscle loss and other side effects.

“It is a time of significant evolution,” said Lee Wright, CEO of The Vitamin Shoppe, in the company’s annual report.

“Innovations such as GLP-1 drugs [are] They are raising awareness about the importance of healthy eating, while social media continues to drive increasing interest in a wide range of health and wellness supplements and products,” Wright added.

Wright told CNBC's “Squawk on the Street” Tuesday morning that growth in weight-loss products was a welcome catalyst after consumers cut back on spending on vitamins and supplements following the pandemic.

The Vitamin Shoppe logo.

John Greim | LightRocket |

The company is increasing its focus on protein supplements, multivitamins, fiber and probiotics through its GLP-1 Nutritional Support program. The Vitamin Shoppe reported a 10% year-over-year increase in sales of ready-to-drink protein beverages in 2023.

Meanwhile, sales of Meal replacement products and unseasoned protein powder rose 13% and 12%, respectively, in the first four months of 2024.

“We work with a panel of doctors and nutritionists to make sure we're giving consumers a holistic approach to their weight loss,” Wright said. “You don't just want to lose weight, you want to lose fat. You want to make sure you're exercising and getting protein as well.”

Wright expects the customer base for weight loss products to triple as more Americans try to lose weight.

In early May, The Vitamin Shoppe also launched its own telemedicine service, Whole Health Rx, which includes access to branded and compounded GLP-1 weight loss medications. Last week, the company added more branded weight loss medications. Options Zepbound and Wegovy as well as the diabetes treatments Ozempic, Mounjaro and Rybelsus, which were already available.

This was the first year that GLP-1 appeared in the company's trend report.

When asked what methods they would seriously consider to control their weight or lose weight, 52% of respondents answered: said they would do more sport and activity, while 26% said they would prefer diet programs. Meanwhile, 17% said they would seriously consider taking GLP-1 drugs.

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Categories
Entertainment

Blueface mom and father alternate heated phrases

Pictures of Blueface's mother have surfaced. Karlissa Saffold Harveyand his father, Johnathan Porterwere involved in a heated exchange of words after Christian RockThe latest arrest.

RELATED: Phew! Chrisean Rock arrested after stopping outside the courthouse to support Blueface (WATCH)

Blueface's mother and father entered IT after Chrisean Rock's arrest

As The Shade Room previously reported, Chrisean Rock was arrested on Monday, June 10, after arriving at the Van Nuys West Courthouse in Los Angeles, California. The mother of one was there to support Blueface, the father of her son Chrisean Jr.

According to The Shade Room, Blueface has been behind bars since January for allegedly violating the terms of his parole.

According to TMZ, Rock was greeted by five LAPD officers as she entered the courthouse. Officers reportedly searched the rapper and then escorted her out of the building in handcuffs. The outlet notes that authorities reportedly took Chrisean Jr. into separate custody.

Ice Cream Convos reports that following Rock's arrest, footage surfaced on social media of Blueface's parents having a heated argument. The two were allegedly arguing over who would babysit Chrisean Jr.

A video of her heated words was shared by a user on X, formerly known as Twitter, @baddietvv. In the clip, Porter Harvey can be heard telling him that he is not a “damn babysitter.”

In response, Harvey Porter asks: “So why are you here?”

“You try to make it about this baby, and it’s about Johnathan [Blueface] today,” counters Porter.

Check out the clip below.

Chrisean Rock arrested and Blueface father doesn't want to look after his junior pic.twitter.com/akIb82jQgW

— The Gworls Fight (@baddietvv) June 10, 2024

Johnathan Porter Provides an update on Chrisean Jr. as social media voices its opinion

On Monday evening, Johnathan Porter posted an update on Chrisean Jr. and his thoughts on the viral events at the courthouse on his Instagram story.

“I went into court today and all my people were waiting for me at the door,” he wrote. “I had to show my ID to get custody of Jr. According to Chrisean he is in good hands with his godmother Marsh and I got her back…”

Before Porter concluded his message, he wrote: “Free Blueface…Free Chrisean.”

Meanwhile, Instagram users have taken to the comments section of Porter's latest post on the platform, with many expressing disappointed reactions to his behavior in the viral clip of him and Harvey.

Instagram user @tinyntatted79 wrote: “HOW CAN YOU ACT LIKE A PROUD GRANDFATHER BUT NOT TAKE JR WITH YOU WHEN CHRISEAN WAS ARRESTED??”

While Instagram user @slimnevashady added, “After what you said in court, I hope Rock never lets you near her son… Karlissa was right about you… I AM VERY DISAPPOINTED AND DISGUSTED IN YOU”

Instagram user @anz.90 wrote: “You're out of line, how can you leave the baby with strangers and then talk about not 'playing grandpa' but you've been 'playing grandpa' all this time on social media but not when it matters, right? Karlissa was 100% right about you”

According to HipHopDX, Karlissa Saffold accused Harvey Porter of entering into a relationship with Chrisean and Chrisean Jr. solely for “influence.”

Blueface's mom says rapper's dad hangs out with Chrisean Rock to have 'influence'

via: @livebitez pic.twitter.com/IdDcYGChkU

— HipHopDX (@HipHopDX), March 23, 2024

That's why Chrisean Rock was arrested

As The Shade Room previously reported, Rock was taken into custody on a felony warrant. The “fugitive warrant” reportedly stems from a case that originated in Oklahoma. Rock was charged in that state in 2022 with “possession of marijuana with intent to distribute and possession of a controlled dangerous substance.”

TMZ adds that Rock's recent arrest was also due to a “charge of assault with a deadly weapon,” but it remains unclear where that charge came from.

According to the Daily Mail, Rock is being held without bail, while TMZ adds that the mother of one could be extradited to Oklahoma.

At this time, no details have been released about Blueface's latest court hearing, but the Daily Mail claims that the rapper will be released from prison on July 2nd.

RELATED TOPICS: Blueface is behind bars, but for how long and why?

Categories
Sport

NBA Finals 2024 – Within the Mavericks’ testing floor for Lukas and Kyrie’s subsequent magic tips

  • Tim MacMahon, editor at ESPNJune 11, 2024, 10:00 a.m. ET

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    • Joined ESPNDallas.com in September 2009
    • Reports on the Dallas Cowboys and Dallas Mavericks
    • Appears regularly on ESPN Dallas 103.3 FM

GOD SHAMMGOD gets into a defensive stance, with the 3-foot padded extensions on each arm serving as a tool against the isolation wizardry of Dallas Mavericks player Luka Doncic.

They're in the middle of a one-on-one match at the Mavs' practice facility, and Shammgod shadows the left side of Doncic's hip to prevent the superstar from executing his signature move.

“You can't go right!” Shammgod yells while defending Doncic on the perimeter. “You can't shoot the step-back right!”

Shammgod knows Doncic will take the taunt as a challenge, but the Mavs' fourth-year assistant and director of player development is simply following the scouting report. Doncic has shot 527 step-back threes during the regular season and playoffs, according to his NBA Advanced Stats shooting splits, and you could count on your fingers the number of times he's gone right.

At least, that was the scouting report until the final seconds of Game 2 of the Western Conference finals. Then Doncic shook off Wolves center Rudy Gobert and fooled the four-time Defensive Player of the Year by stepping back to his right and making the game-winning three-pointer. It was the first time all postseason that Doncic didn't go left on his step-back three-pointer, as he prefers.

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But Shammgod and the other Mavs assistants weren't surprised. They've had issues with the move all season.

They had seen Doncic throw plenty of stepbacks with the right-hand batter in the one-on-one sessions after practice, with Doncic and his backcourt partner Kyrie Irving taking turns attacking the rotating trio of assistants, which also includes Darrell Armstrong and Marko Milic.

And just as they noticed Doncic's new variation on his stepback, Irving had thrown a ton of 20-foot southpaw hook shots in front of Shammgod & Co. before sinking one on the final buzzer to shock the defending champion Denver Nuggets in March.

“We're just trying new things,” Doncic told ESPN of the 30- to 60-minute sessions. “We're smiling and just playing basketball. That's what it's about.”

And as Dallas prepares to host the Boston Celtics in Game 3 of the NBA Finals on Wednesday (8:30 p.m. ET on ABC), Doncic and Irving will draw on the close bond they've built while expanding their arsenal of scoring opportunities.

“This is definitely the crafting table,” Irving told ESPN. “We just work on our craft when nobody's watching. We have a lot of fun, man. It's always fun when you see someone working on things that they don't necessarily show a lot in the game, but you know they've got it.”

God Shammgod joined the Dallas Mavericks coaching staff in 2019, a year after Luka was drafted. (Photo by Brian Babineau/NBAE via Getty Images)

SHAMMGOD'S PADS ARE NOT the only way the Mavs' middle-aged assistant coaches are trying to catch up on the court against two of the NBA's most talented playmakers.

“They're only doing two or three dribbles now. They're not doing 16 dribbles,” Armstrong, 55, told ESPN. “They're only doing two or three to help us.”

Armstrong earned a reputation as a tenacious defender during his 14-year NBA career, with the high point of his career being named Sixth Man and Most Improved Player of the Year in the 1998-99 season.

His feet aren't quite as quick—and it probably doesn't help that he only wears low-top Chuck Taylors when he practices—but he says his swipe-down move is still as effective as ever, and he tirelessly badmouths Doncic and Irving, regardless of the outcome.

“I mean, I'll lock them up,” Armstrong boasted playfully.

Doncic, meanwhile, raised his voice when Armstrong's claim was relayed.

“Oh, hell no! DA?! No!” Doncic barked, grinning as he shook his head. “You know that's not true.”

Armstrong, of course, readily admits that Doncic is right. His constant chatter is meant to lighten the mood while also stoking the competitive spirit of Doncic and Irving.

Darrell Armstrong joined the Dallas Mavericks coaching staff midway through the 2008-09 season and is now in his tenth year as an assistant coach. Jerome Miron-USA TODAY Sports

“It's really just about getting them going and getting them to do good work,” Armstrong said. “It's just fun to not be serious but be competitive. I talk shit and get my ass kicked.”

“You already know that Lukas talks shit, but Kai is also underhanded. Kai is underhanded. The way they treat us, I can't blame them.”

Armstrong had been part of the Mavs' coaching staff for a decade, even before Doncic arrived in Dallas, but the relationships between Doncic and Milic and Irving and Shammgod go back much further.

Milic, 47, was the first NBA player from Slovenia, a powerful, springy 6-foot-6 forward who played 44 games as a teammate of Jason Kidd on the Phoenix Suns from 1997-99 before returning to Europe. Milic was a teammate of Doncic's father, Sasa, during Slovenian club Union Olimpija's 2007-08 Adriatic League championship season when young Luka was a ball boy. Milic, an assistant coach for the Slovenian national team, joined the Mavs' coaching staff before last season.

Shammgod, 48, a New York native known for his ball-handling wizardry, has been friends with Irving's father, Drederick, and Kyrie's godfather, former NBA star Rod Strickland, for decades. Irving's relationship with Shammgod, who joined the Mavs' staff in 2019, was one of the factors that made the eight-time All-Star feel comfortable after arriving in Dallas via trade following a tumultuous two-and-a-half-year tenure with the Brooklyn Nets.

“For [Doncic and Irving]there are so many developments,” said Shammgod. “It's great. It's like a painting where I have this beautiful canvas and I can just keep adding more things to the canvas.”

DONCIC AND IRVING have never played one-on-one against each other — “Next year we'll try,” Doncic said — but they still compete against each other in practice sessions and in regular free-throw and 3-point contests.

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If Doncic makes a move that leaves the crowd speechless, Irving will try to imitate it or outsmart him. And vice versa.

“He does crazy things that I can't do, but sometimes I try,” said Doncic, one of many current or former players who have called Irving the most skilled ball handler in the history of the game.

“That's healthy creativity, man, and that's what you want,” Irving said. “Call it osmosis. We're in that environment together. He's trying new moves, I'm trying new moves. We're picking things up and adding them to our game.”

Sometimes the moves are spontaneous. On other occasions, Doncic and Irving take suggestions from Shammgod, who played only 20 games for the Washington Wizards in his NBA career but enjoys a unique reputation among current players.

Shammgod, who has a Puma contract for his own shoes, is widely considered one of the most creative ball handlers in the history of the game. There is a famous one-handed crossover commonly known as “The Shammgod,” a move Doncic used in his warm-up before Game 1 of the NBA Finals while being covered by the namesake himself.

Doncic and Irving are more than receptive to Shammgod's feedback, which often involves a tip on a seemingly tiny detail, like Doncic working on doing his usual stepback after passing between his legs from left to right, rather than always having to pick up his dribble with his left hand.

Kyrie Irving joined the Dallas Mavericks at the 2023 trade deadline after a controversial stint with the Brooklyn Nets earlier in the season. (Photo by Jesse D. Garrabrant/NBAE via Getty Images)

“Players like them,” Shammgod said, “give you little things and then they just make it bigger. They make it bigger with their imagination. It sounds insignificant, but to great players, the little things are significant.”

In many cases, you'd think Doncic and Irving were just joking around. The harder a shot is, the more fun it is.

But there's a practical reason for this kind of competitive art. You never know if a late-game moment during the Finals will call for a left-handed shot from outside the crease or a sidearm bank shot from 3-point range, like Doncic did for a crucial basket in an early-season win over the Nets.

“They miss a lot of shots in training,” said Milic. “But they are ready for the game, for special occasions.”

“They have these extra surprise moves – a surprise for us. For them, they make it look natural.”

Categories
Science

Up to date hydrogen price calculation – What’s occurring with it?

By NOT MANY PEOPLE KNOW THAT

By Paul Homewood

The cost of manufacturing and installing electrolyzers for green hydrogen production in China, the US and Europe – three of the world's largest markets – has increased by more than 50 percent year-on-year, according to research institute BloombergNEF (BNEF). However, in its analysis, this had not led to a gradual reduction, as had previously been indicated.

The main culprit for Western manufacturers is inflation, which has driven up the cost of materials, utilities (such as water and electricity) and labor in the U.S. and Europe, BNEF said in its new report, “Electrolyser Price Survey 2024.”

As a result, the average system cost (including chimney and residual plant) for an electrolyzer made in China is now in the mid-range of US$600/kW, while machines made in Europe or the US cost around US$2,500/kW.

This makes Western electrolyzers four times more expensive than their Chinese counterparts, and this gap has not closed since the last report, BNEF noted.

The research institute had previously predicted that costs would gradually decline over a three-year period starting in 2022 as more and more major projects moved closer to completion.

https://www.hydrogeninsight.com/electrolysers/cost-of-electrolysers-for-green-hydrogen-production-is-rising-instead-of-falling-bnef/2-1-1607220

Green hydrogen, once touted as the savior of net-zero emissions, seems to have faded from the scene recently. A few years ago, there were wild, unproven predictions that hydrogen would be so cheap and easy to produce that we could all do without fossil fuels.

Instead, Bloomberg now reports, the costs of electrolyzers are rising instead of falling. In addition, the real costs of wind energy are much higher than previously thought, so green hydrogen is becoming significantly more expensive as a result.

So let’s take a closer look at these costs.

BEIS published this report back in 2018:

https://www.gov.uk/government/publications/hydrogen-supply-chain-evidence-base.

I analyzed the report here.

This table was included:

I expect PEM (Proton Exchange Membrane) technology to be the most likely to be adopted, with base cost in 2025 estimated at £500/kW.

A study last October put the average price at €727, or about £630 per kilowatt. Bloomberg puts it at $600, but that's based on extremely low Chinese production costs, which are almost certainly heavily subsidised. Tellingly, it's estimated that electrolysers made in Europe are four times as expensive.

We can therefore reasonably estimate costs to be in the region of £600.

The BEIS study assumed 52.0 kWh/kg H2 in 2025. However, the energy density of hydrogen is 33.3 Kwh per kg, which means that the electrolysis process only works at 64% efficiency. In other words, 36% of the energy used is lost.

Previous cost estimates were based on the lowest cost of renewables, in particular offshore wind, which would have to provide the majority of the electricity needed for electrolysis in the UK. As we now know, these costs were never realistic. The administrative strike price for offshore wind for AR6 is now £100/MWh at 2023 prices. Therefore, taking into account an energy efficiency of only 64%, the energy input cost of hydrogen is £156/MWh.

Then there are the running costs. BEIS calculated £21/MWh in 2018, which is now probably in the region of £30.

So we are already at £186/MWh, without adding in the capital costs. BEIS estimated this to be around £30/MWh in 2018, but this assumed a loan interest rate of 5%. Given the rise in interest rates since then and general inflation, a capital expenditure of £60/MWh is not unreasonable.

The total cost is therefore £246/MWh.

Wholesale natural gas prices have ranged from 55p to 85p per therm this year. The conversion rate is 29.3kWh per therm, giving a cost of £23.90 per MWh, based on a mean of 70p.

Does anyone still think hydrogen is a good idea?

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Health

FDA advisers advocate Eli Lilly’s Alzheimer’s drug donanemab

Eli Lilly headquarters in Indianapolis, Indiana, U.S., on Wednesday, May 3, 2023. Eli Lilly & Co. shares rose in early U.S. trading after its experimental Alzheimer's drug slowed the progression of the disease in a late-stage trial, paving the way for the company to seek U.S. approval.

AJ Mast | Bloomberg |

A panel of independent advisers to the Food and Drug Administration recommended on Monday Eli LillyThis paves the way for the treatment to be fully approved in the United States later this year.

The FDA typically follows the recommendations of its advisory panels, but is not required to do so. If Eli Lilly's donanemab is approved, it would be the second Alzheimer's drug of its kind to hit the U.S. market, following another drug called Leqembi from Biogen and its Japanese partner Eisai.

Approval would expand the currently limited treatment options for the more than six million Americans who suffer from Alzheimer's disease. Alzheimer's is the fifth leading cause of death in adults over 65.

In an initial vote, 11 committee members unanimously said available data on the drug showed it was effective in treating Alzheimer's patients in the early stages of the mental illness. However, several advisers noted that more data on donanemab in black and Hispanic patients and other groups are needed.

In a second vote, the advisers unanimously declared that the benefits of Eli Lilly's donanemab outweighed the risks.

“There is a huge unmet medical need here that hopefully can be met,” said Sarah Dolan, interim committee member, during a meeting Monday. Dolan is a consultant for the nonprofit Critical Path Institute, whose goal is to improve the drug development process.

The recommendation follows the obstacles Eli Lilly faced in bringing the drug to market.

In March, the FDA convened a last-minute advisory panel meeting to further review the safety and effectiveness of Eli Lilly's drug in a late-stage trial, just weeks before the agency's deadline to decide on the treatment.

This was another setback for Eli Lilly. The company had originally expected donanameb to be approved at the end of last year. The FDA also rejected the drug in January last year because there was not enough data for approval.

Leqembi and donanemab are milestones in the treatment of Alzheimer's after efforts to develop drugs to treat the deadly disease failed for three decades.

Both drugs are monoclonal antibodies that target the amyloid plaques in the brain that are considered a hallmark of Alzheimer's disease and slow the progression of the disease in early-stage patients.

But none of the treatments is a cure.

Drugs that specifically clear amyloid plaques can also cause brain swelling and bleeding in patients, which in some cases can be serious and even fatal. Three patients taking Eli Lilly's drug in a late-stage trial died from severe cases of these side effects, called amyloid-related imaging abnormalities, or ARIA.

A number of hurdles have delayed Leqembi's launch since its approval in July, including the steps needed to diagnose Alzheimer's and monitoring and managing the weekly infusions required with the drug. Biogen and Eisai signaled in April that they were seeing increasing uptake.

In a note on Sunday, David Risinger, an analyst at Leerink Partners, said he expected limited commercial acceptance of donanemab compared to leqembi because Eli Lilly's drug has “more safety risks” and is less convenient because it is administered once a month through a vein, a method known as an intravenous infusion.

Leqembi is currently given as an infusion twice a month, but Biogen expects to launch an injectable version of the drug next year, Risinger noted. He expects donanemab to generate $500 million in sales by the end of the decade.

How effective is Eli Lilly’s Alzheimer’s drug?

Eli Lilly's Phase 3 trial of more than 1,700 patients found that donanemab slowed the progression of Alzheimer's disease by 29% compared with placebo after about 18 months, based on a traditional tool for measuring dementia severity.

These results are comparable to those of Leqembi.

Patients in Eli Lilly's Phase 3 trial had to test positive on a PET scan for amyloid plaques and another protein in the brain called tau, which is considered a marker of the severity of Alzheimer's disease. People with no or very low levels of tau were not included in the trial's primary analysis because researchers thought their disease would be less likely to progress during the trial.

Eli Lilly's study focused primarily on patients with low to moderate tau levels, who appeared to benefit more from treatment than patients with high tau levels.

Westend61 | Westend61 |

Eli Lilly argued that patients needed to be tested for amyloid plaque to be eligible for the drug, not tau. The company said it tested for tau in the trial to include patients whose conditions were expected to worsen, making it more likely that the trial could “clearly determine” the drug's effects.

Most advisers agreed that tau testing should not be required for access to donanemab, as this would likely limit the number of people who can benefit from the drug.

“From a very practical perspective, I don't think it's wise to put in place such an obstacle,” said Dr. Kathleen Poston, temporary committee member and professor of neurology, neuroscience and neurosurgery at Stanford University, during Monday's meeting.

Patients who took Eli Lilly's drug as part of the study were able to switch to a placebo if the amyloid level in their brain fell below a certain threshold. At the end of the study, 60 percent of participants who received donanemab were able to stop treatment.

Dolan said the ability to stop the drug once enough amyloid has been cleared could be a “motivational factor” for patients to stick with their infusions and regular testing.

Risks of brain swelling, bleeding

About 24% of study participants taking donanemab experienced brain swelling, while 31% experienced brain hemorrhage.

The majority of these ARIA cases were mild to moderate, with 6% of participants with brain swelling and 1% with brain hemorrhage experiencing symptoms including headache, confusion, dizziness, nausea, and in rare cases, seizures.

Severe cases occurred in 1.5% of patients with brain swelling and in less than 1% with cerebral hemorrhage.

If donanemab is approved, FDA officials expect the drug's label to include a prominent warning about the risks of brain swelling and bleeding, especially in people with two copies of a gene called ApoE4. They also expect to recommend MRIs to monitor these side effects in patients, among other strategies.

This is in line with the Leqembi seal of quality.

According to a final data analysis by FDA staff, there were 19 deaths among participants taking donanemab during the 18-month trial, including three attributed to Eli Lilly's drug, compared with 16 deaths on placebo, reflecting a smaller imbalance in the number of deaths between people taking donanemab and those not taking it.

Categories
Technology

EU unveils AI-powered ‘digital twin’ of Earth

The European Commission today launched the first version of Destination Earth (DestinE), an AI-powered simulator to improve the accuracy of climate forecasts.

The first version of DestinE includes two models: one for extreme weather events and another for climate change adaptation. These models will monitor, simulate and predict the Earth's climate in detail.

“DestinE means we can monitor environmental problems that can help us predict future scenarios – like never before,” said EU Antitrust Commissioner Margrethe Vestager.

DestinE is powered by Europe's high performance computing (EuroHPC), including the LUMI supercomputer in Finland. The developers have combined this with AI to increase data processing speed.

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“This first phase shows how much we can achieve when Europe pools its scientific excellence and its enormous supercomputing capacity,” said Vestager.

However, the overall model is expected to evolve over time, with a complete digital twin of the Earth expected to be available by the end of this decade.

Digital twin of the earth

Do you want to test how a heatwave will affect food security? Or whether a storm will flood a particular city? Or where to best place your wind farm? All of this could be possible with the digital twin of the Earth.

The digital twin will draw on a vast pool of data for its predictions and simulations. This information will come from satellites such as those of the EU's Copernicus programme. It will also come from IoT sensors on the ground as well as a wealth of government data.

To complete the digital twin of the Earth, future versions will include data from oceans, cities, forests – basically any place on our planet that scientists can analyze.

The EU first launched DestinE in 2022. Over 300 million euros have been made available for the construction of the digital twin.

Today's launch marks the end of the first phase and the beginning of the second phase, each of which will receive funding of over 150 million euros.

The financing of the third phase is subject to the approval of the final Digital Europe 2025-2027 programme, which is currently being prepared.

The EU is far from the only organisation working on this type of technology. In March Nvidia introduced its own digital twin of our planet called Earth-2. According to the chip giant, the Taiwanese government is already using the model to better predict when typhoons will hit land.

Categories
Science

As an alternative of dropping its ambiance, an exoplanet swelled up and held onto it

To date, astronomers have confirmed the existence of 5,638 extrasolar planets in 4,199 star systems. In the process, scientists have discovered many worlds that have exceeded all expectations. This is certainly true of the “hot Neptunes,” planets that resemble the “ice giants” of the outer solar system but orbit much closer to their stars. However, when a team of astronomers led by Johns Hopkins University discovered TIC365102760 b (also known as Pheonix), they observed something completely unexpected: a planet the size of Neptune that maintained its atmosphere by puffing up.

Sam Grunblatt, an astrophysicist in JHU's William H. Miller III Department of Physics and Astronomy, led the research. He was joined by an international team that included Nicholas Saunders, NSF Graduate Research Fellow, Shreyas Vissapragada, Steven Giacalone, Ashley Chontos and Joseph M. Akana Murphy, 51 Pegasi b Fellows, and researchers from many prestigious institutes and universities. The paper describing their findings (which recently appeared in the Astrophysical Journal) is part of a series called “TESS Giants Transiting Giants.”

Artist's impression of JG436b, a hot Neptune located about 33 light-years from Earth. Image credit: STScI

Puff planets are a new class of incredibly rare exoplanets, estimated to make up 1% of all planets in our galaxy. The team discovered Pheonix by combining data from the Transiting Exoplanet Survey Satellite (TESS) with radial velocity measurements obtained by the High Resolution Echelle Spectrometer (HIRES) at the Keck Observatory. Their data showed that Pheonix is ​​0.55 times the size of Jupiter but only 0.06 times as massive, and orbits a red giant star with a period of 4.21285 days (about six times closer to its star than the distance between Mercury and the Sun).

Based on the age and temperature of its star, as well as the planet's remarkably low density, the team hypothesized that Phoenix's gaseous envelopes must have been separated billions of years ago. Based on its density, the team also estimates that the planet is the most bloated “puff planet” yet (about 60 times less dense than the densest “hot Neptune”) and that it will begin rotating into its star in about 100 million years. As Grunblatt explained in a JHU HUB press release:

“This planet is not evolving as we thought. It appears to have a much larger, less dense atmosphere than we expected for these systems. How it was able to retain this atmosphere despite being so close to such a large parent star is the big question.”

“It is the smallest planet we have ever found around one of these red giants, and probably the lowest-mass planet that has a [red] “The biggest star we've ever seen. That's why it looks really strange. We don't know why it still has an atmosphere, while other 'hot Neptunes', which are much smaller and denser, seem to lose their atmosphere in much less extreme environments.”

Artist's impression of Phoenix, the “hot Neptune” orbiting a red giant star 8 billion light-years from Earth. Image credit: Roberto Molar Candanosa/JHU

These findings could provide new insights into the late evolution of planetary systems and help scientists predict what will happen to the solar system in a few billion years. According to standard models of stellar evolution, our sun will exit its main sequence phase, expand into a red giant, and eventually engulf the inner planets. Based on these findings, they predict that Earth's atmosphere may not evolve as astronomers previously expected. Instead of our sun blasting it away, our atmosphere could expand and become incredibly “puffy.”

Pheonix is ​​the latest bloated planet that the international team has studied using TESS data. While bloated planets are considered rare, exoplanets like Pheonix are particularly difficult to find due to their small size and low density. In the future, Grunblatt and his colleagues plan to search for more of these smaller worlds and have already identified a dozen potential candidates by combining transit and radial velocity data.

Further reading: John Hopkins University, The Astrophysical Journal

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Categories
Entertainment

Go full throttle and catch the Velocity ​​​​Forged then and now

Besides Joe Morton, you've seen Grant in everything. Probably more of everything.

Her career began in 1979. Since playing the fatally impatient Helen in “Speed”, she has appeared on television in the series “Friends”, “Sabrina the Teenage Witch”, “Angel”, “The X-Files”, “CSI”, “Malcolm in the Middle”, “Everwood”, “Six Feet Under”, “Bones”, “Jericho”, “Pushing Daisies”, “Criminal Minds”, “King of the Hill”, “Modern Family”, “Dexter”, “Justified”, “Grey's Anatomy”, “American Gods”, “The Mindy Project”, “A Series of Unfortunate Events”, “Goliath”, “Dollface” and “Grace & Frankie”.

At the same time, it moves seamlessly between well-known indie films and major cinema films: Todd Haynes“Safe, the jury, Dr. Dolittle, Donnie Darko, Pearl Harbor, Matchstick Men, Little Miss Sunshine, Flags of Our Fathers, No Country for Old Men, Crazy Heart, The Artist, Jackie and Amsterdam.”

“Turn on your television in the evening, one of the movie channels,” says The Mindy Project. Ike Barinholtz he told the Wilmington Star-News in 2013: “And count how many minutes it takes for Beth Grant to appear in one of these movies.”

Grant is also the mother of an actress Maria Chieffo with her husband, the actor, since 1985 Michael Chieffo (which you have also seen in many things!).