Out of masterresource
By Robert Bradley Jr.
“Internal organs are sensitive to noise and vibration. The current state of knowledge about mechanotransduction as well as known oscillatory and oxidative stress effects point in the direction of our hypothesis and should prompt urgent precautions and further research.”
It's a very technical topic – but certainly one for deep ecologists who see humanity as a cancer on optimal, fragile nature. Industrial wind turbines, huge and disruptive to the outdoors, are certainly man-made and subject to the “guilty until proven innocent” doctrine of the “Precautionary Principle.”
Infrasound and low-frequency noise (ILFN) is an important topic that wind advocates do not want to discuss or debate. MasterResource contributions by Stephen Cooper and others over many years have demonstrated that “what you can't hear can harm you.” As one critic put it:
Industrial wind turbines have more than just audible noises, grinding, whining, the whooshing of blades and a pervasive hum. They have a silent, barely audible effect. It's not like workplace contamination/harm where people can go home at night to find relief. With industrial wind projects literally devouring homes and rural areas, there is little to no way out.
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The ILFN debate continues. In the June 2023 issue of the Journal of Biosciences and Medicines (Vol. 11; No. 6), “Impairment of the endothelium and disruption of microcirculation in humans and animals exposed to infrasound due to irregular mechanotransduction,” says Ursula Maria Bellut-Staeck presented an important hypothesis that the mainstream should discuss (and not ignore). The summary and conclusion follow.
Abstract
Mammalian microcirculation is an autoregulated and complex synchronized system according to current needs for nutrients and oxygen. The undisturbed functioning of vital functions such as growth, blood pressure regulation, inflammation and embryogenesis is tied to the integrity of the endothelium. Sensitive vasomotion is particularly dependent on this.
Mechanotransduction signaling networks play a crucial role in vital cellular processes and are the key physiological mechanism for appropriate NO release, mainly responsible for vascular autoregulation. A disturbed endothelial integrity, which is caused, for example, by chronic oxidative stress and/or mechanical (oscillating) stress, leads to a disturbance of vasomotion and an imbalance of the redox systems, which is considered to be the main cause of the development of chronic inflammatory diseases such as arteriosclerosis, corresponding secondary diseases, if necessary. Cancer.
The endothelial cytoskeleton, which corresponds to a viscoelastic “tensegrity model”, offers the possibility of mechanotransduction due to its special structure. The rapidly growing knowledge of mechanical forces in cellular sensing and regulation in recent years (culminating in the award of the Nobel Prize for the decoding of pressure/vibration-sensitive ion channels) led us to the following hypothesis: The external stressor “noise” produces under certain conditions Conditions create an oscillating tension field in the physiologically laminar flow bed of the capillaries, which can lead to irregular mechanotransductions. The results provide a strict frequency dependence in mechanotransduction with the determination of thresholds for 1:1 transmission.
Recent insights into endothelial mechanotransduction shed new light on the importance of low frequencies. This could be a clue to the long-sought pathophysiological way in which infrasound can exert a stressor effect at the cellular level. Noise-exposed citizens who live near infrastructure such as a biogas plant, heat pumps, combined heat and power plants and larger industrial wind turbines (IWT) worldwide predominantly exhibit symptoms associated with microcirculation disorders. Effects on insects or fish are also conceivable, as the piezo channels are considered to be conserved structures of all multicellular organisms.
An experimental design is proposed to demonstrate the direct pathological influence of infrasound of defined strength, frequency, action/time profile and duration on sensory vasomotion.
Conclusions
For the first time, the symptoms of people and animals chronically exposed to infrasound can be classified pathophysiologically in a coherent hypothesis. This has been made possible by advances in knowledge of endothelial mechanotransduction, which is essential as a vital vascular function in response to mechanical forces. Crucial cellular processes such as growth, differentiation, migration, angiogenesis, redox homeostasis and inflammation are simultaneously dependent on mechanical forces and the integrity of the endothelium.
Normally, flow in the mammalian microcirculation is laminar and not variable. This is achieved by the upstream connection of resistance vessels in the arterioles. Sustained changes in shear stress patterns, particularly oscillatory flow, have been associated with reduced NO bioavailability, increases in reactive oxygen species (ROS), higher lipoprotein oxidation rates, increased endothelial apoptosis, proatherogenic effects, chronic inflammation and possible carcinogenesis.
We have positive evidence for our hypothesis that a chronically acting oscillating stressor with certain conditions in frequency, time/action profile, sound pressure and duration could induce an oscillating stress field and thus trigger a stress response at the cellular level. With the crucial foundations of mechanotransduction, there is now strong evidence with obvious indicators of a possible interaction of infrasound, especially with low frequencies and impulsive character, as is the case for example with IWTs or heat pumps. The elucidation of the strong dependence of mechanotransduction on the frequency of “noise” and the identification of actin filaments and microtubules as “low-pass filters” support our hypothesis.
In this way, the propagation of the sound wave in the viscoelastic organism could become decipherable information. Regeneration, as would occur with a one-time or rare exposure, cannot take place with chronic exposure. Initially, functional disorders of the orchestrated vasomotor system or the sensitive vasomotion are to be expected; with prolonged exposure, anatomically recognizable pathological damage to the endothelial integrity occurs. What is important in this context are the structural changes that tend to be self-reinforcing, as described using the example of the remodeling of the heart.
By potentially elucidating the pathophysiological pathway by which infrasound/IFLN could lead to major health disorders, it will be possible to make progress in establishing safety distances for living or working with emitting technological equipment. Many scientific questions remain to be answered, but there is enough evidence to suggest that, as a precautionary measure, further technologies involving very low frequencies and/or pulsed emissions with potential effects on living organisms should be limited or better avoided until all problems are resolved scientifically solved. The possible effects on insects, which are not yet clear, could be of great importance, for example for biodiversity and for the participation of pollinators and thus for nutrition.
The decryption of the PIEZO-1 channels should have already alerted the public to the possible risks. Internal organs are sensitive to noise and vibration. The current state of knowledge on mechanotransduction as well as known oscillatory and oxidative stress effects point in the direction of our hypothesis and should be a reason for urgent precautions and further research.
Final comment
Will “ExxonKnew” be replaced by “Industrial Wind Knew” in future litigation? When did the problem of infrasound and low-frequency noise first arise, and have trade groups in the U.S. and abroad noted and investigated the problem? The future of dilute, intermittent, inefficient, land-intensive and noise-intensive industrial wind energy is part of Earth in the Balance.
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